361565
GSK3β Inhibitor XIX, IM-12
The GSK3β Inhibitor XIX, IM-12 controls the biological activity of GSK3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
GSK3β Inhibitor XIX, IM-12, IM-12
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About This Item
Empirical Formula (Hill Notation):
C22H20FN3O2
Molecular Weight:
377.41
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange-yellow
solubility
DMSO: 100 mg/mL
DMSO: soluble
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Schmole, AC., et al. 2010. Bioorg. Med. Chem.18, 6785.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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