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Merck

1.37028

SAFC

Glycerol

greener alternative

anhydrous (vegetable), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP, ACS

Pharma Manufacturing

Synonym(s):

1,2,3-Propanetriol, Trihydroxylpropane, Protol, Glycerin, 1,2,3-Propanetriol, Glycerin

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About This Item

Linear Formula:
HOCH2CH(OH)CH2OH
CAS Number:
Molecular Weight:
92.09
Beilstein:
635685
MDL number:
UNSPSC Code:
12352104
EC Index Number:
200-289-5

grade

ACS reagent

Quality Level

Agency

BP
ChP
JP
Ph. Eur.
USP

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

product line

EMPROVE® EXPERT

Assay

≤98.0-101.0% (calculated on anhydrous substance, alkalimetric)
≥99.5% (calculated on anhydrous substance, GC)

form

liquid

autoignition temp.

698 °F

expl. lim.

2.6-11.3 % (v/v)

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

electrophoresis: suitable

refractive index

n20/D 1.474 (lit.)

pH

5 (20 °C, 100 g/L in H2O)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

transition temp

flash point 199 °C

density

1.25 g/mL (lit.)

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical

greener alternative category

storage temp.

2-30°C

SMILES string

OCC(O)CO

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a bio-based glycerol and is aligned with the 5th principle of Green Chemistry "Safer Solvents and Auxiliaries" and 7th principle "Use of Renewable Feedstock". Click here for more details.

Application

Glycerol can be used in a wide variety of solid, semi-solid and liquid formulations, including ophthalmic, oral solid and oral liquid dosages, tablet coatings, creams and gels. It is applied for its humectant, emollient, solvent/cosolvent, viscosity increasing, and plasticizer properties.
Glycerol anhydrous (vegetable) Emprove® Expert is low in endotoxins and bioburden, making it the right choice for your high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

390.2 °F

Flash Point(C)

199 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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