P-103
Posaconazole solution
2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
About This Item
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
2.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
room temp
InChI
1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
InChI key
RAGOYPUPXAKGKH-XAKZXMRKSA-N
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General description
Application
- Pharmacokinetic modeling in pediatric patients: Posaconazole intravenous solution and oral powder suspension formulations are studied for their pharmacokinetics in pediatric patients with neutropenia, highlighting the solution′s role in optimizing dosing regimens (Winchell et al., 2024).
- Enhanced solubility and bioavailability: Posaconazole antifungal solution is utilized in the development of amorphous solid dispersions with poly(vinylpyridine-co-vinylpyridine N-oxide) excipients, which mediate rapid dissolution and sustained supersaturation, improving its therapeutic efficacy (Liu et al., 2024).
- Nanoformulation for oral delivery: A posaconazole-loaded phospholipid-based nanoformulation developed through design of experiments, machine learning, and TOPSIS optimizes oral delivery, enhancing the antifungal′s absorption and therapeutic profile (Bayat et al., 2024).
- Cost-utility analysis in fungal prophylaxis: Research on posaconazole solution′s cost-effectiveness in preventing invasive fungal infections among leukemia patients undergoing chemotherapy underscores its potential economic benefits in healthcare settings (Pungprasert et al., 2024).
- Cerebrospinal fluid concentrations: Studies assessing the concentrations of posaconazole in cerebrospinal fluid of pediatric leukemia patients validate the solution′s penetration and potential effectiveness in treating central nervous system infections (Körholz et al., 2024).
Legal Information
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
49.5 °F
Flash Point(C)
9.7 °C
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
EU REACH Annex XVII (Restriction List)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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