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LM1000

Avanti

12:0-13:0 PC

Avanti Polar Lipids LM1000, methanol solution

Synonym(s):

1-dodecanoyl-2-tridecanoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C33H66NO8P
CAS Number:
1246304-45-9
Molecular Weight:
635.85
UNSPSC Code:
12352211
NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (LM1000-1EA)

manufacturer/tradename

Avanti Polar Lipids LM1000

concentration

~10 μg/mL (Refer to C of A for lot specific concentration.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)=O

General description

Phospholipids are major structural biomolecules found in biological membranes. Phosphocholine (PC) is an intermediate of phosphatidylcholine synthesis catalyzed by choline kinase.

Application

12:0-13:0 PC or 1-dodecanoyl-2-tridecanoyl-sn-glycero-3-phosphocholine has been used:
  • as an internal standard in liquid chromatography/mass spectrometry (LC/MS) analysis
  • as a lipid standard for phospholipid quantification by MS
  • as an internal standard for the retention time recalibration during LC-MS data processing
  • as an MS grade lipid standard for lipid extraction from macrophages

Biochem/physiol Actions

Phospholipids participate in protein mediated intracellular and extracellular signaling processes.

Packaging

2 mL Amber Glass Sealed Ampule (LM1000-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Akifumi Shiomi et al.
Bioscience, biotechnology, and biochemistry, 84(3), 583-593 (2019-11-26)
Fish cell lines are widely used for the studies of developmental biology, virology, biology of aging, and nutrition physiology. However, little is known about their physicochemical properties. Here, we report the phospholipid compositions and mechanical properties of cell membranes derived
Shayne A Snider et al.
The Journal of biological chemistry, 293(29), 11600-11611 (2018-06-09)
Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine. Macrophages are innate immune cells that survey and respond to danger and damage signals. Although it is well-known that energy metabolism can dictate macrophage
Penelope Dimas et al.
eLife, 8 (2019-05-08)
Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL
Bingpeng Yan et al.
International journal of molecular sciences, 20(23) (2019-11-30)
Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the most common causes of hand, foot, and mouth disease. Severe EV-A71 and CV-A16 infections may be associated with life-threatening complications. However, the pathogenic mechanisms underlying these severe clinical and pathological features
Ulrike Bruning et al.
Cell metabolism, 28(6), 866-880 (2018-08-28)
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASNKD) in ECs impedes vessel sprouting by reducing proliferation. Endothelial loss of FASN impaired angiogenesis in vivo, while FASN blockade reduced

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