890880P
Avanti
18:0 TAP
Avanti Polar Lipids 890880P, powder
Synonym(s):
1,2-stearoyl-3-trimethylammonium-propane (chloride salt)
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About This Item
Empirical Formula (Hill Notation):
C42H84NO4Cl
CAS Number:
Molecular Weight:
702.57
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 200 mg (890880P-200mg)
pkg of 1 × 25 mg (890880P-25mg)
manufacturer/tradename
Avanti Polar Lipids 890880P
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Cl-]
Application
1,2-stearoyl-3-trimethylammonium-propane (18:0 TAP) might be used:
- for the preparation of tri-loaded bilosomes (Tri-BLs) by thin film hydration technique
- to formulate lipid nanoparticles (LNPs), for testing its efficiency of packaging mRNA into an LNP
- to fabricate unilamellar empty liposomes
- to prepare lipoplexes
Biochem/physiol Actions
1,2-stearoyl-3-trimethylammonium-propane (18:0 TAP) is a cationic lipid used in DNA transfection.
Packaging
5 mL Amber Glass Screw Cap Vial (890880P-200mg)
5 mL Amber Glass Screw Cap Vial (890880P-25mg)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hailing Yang et al.
Drug delivery, 26(1), 820-830 (2019-08-08)
Arthritis treatment has been challenging because of low drug exposure to the articular cavity. This study was intended to develop hyaluronic acid (HA)-functionalized bilosomes for targeted delivery of tripterine (Tri), an antiphlogistic phytomedicine, to the inflamed joint via ligand-receptor interaction.
Maria Jose York-Duran et al.
Biomaterials science, 7(11), 4813-4826 (2019-09-20)
While ROS display crucial functions in many physiological processes, elevated ROS levels are also related to the initiation and progression of many severe diseases such as cancer, cardiovascular conditions or neurologic disorders. Research approaches to diminish ROS levels during disease
A E Regelin et al.
Biochimica et biophysica acta, 1464(1), 151-164 (2000-03-08)
In order to investigate the relationship between lipid structure and liposome-mediated gene transfer, we have studied biophysical parameters and transfection properties of monocationic DOTAP analogs, systematically modified in their non-polar hydrocarbon chains. Stability, size and (by means of anisotropy profiles)
Yuki Takechi-Haraya et al.
Langmuir : the ACS journal of surfaces and colloids, 34(26), 7805-7812 (2018-06-06)
It has recently been recognized that the mechanical properties of lipid nanoparticles play an important role during in vitro and in vivo behaviors such as cellular uptake, blood circulation, and biodistribution. However, there have been no quantitative investigations of the
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