790625P
Avanti
DC-Chol/DOPE Blend
Avanti Polar Lipids 790625P, powder
Synonym(s):
DC-Chol/DOPE Blend, DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w)
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 25 mg (790625P-25mg)
manufacturer/tradename
Avanti Polar Lipids 790625P
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
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General description
DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (DOPE) lipid complex comprises the cationic lipid DC-Cholesterol and the neutral helper lipid DOPE.
Application
DC-Chol/DOPE Blend has been used:
- in the preparation of liposomes for ferritin heavy chain 1 (FTH1) siRNA (small interference RNA) transfection studies
- to compare its cytotoxicity tests with ginger derived nanoparticles in colon-26 cells
- as a standard control in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to evaluate biocompatibility of ginger derived lipid vesicles
Biochem/physiol Actions
DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w) helps in transfection of therapeutic small interference RNA (siRNA). DC-Chol/DOPE liposomes are cationic, unilamellar and spherical in nature. It aids in improved condensation of DNA for transfection studies.
Packaging
5 mL Clear Glass Sealed Ampule (790625P-25mg)
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this
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