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900760

Sigma-Aldrich

Sodium 5-(trifluoromethyl)pyridine-2-sulfinate

≥95%

Synonym(s):

Willis 5-trifluoromethyl pyridine 2-sulfinate

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About This Item

Empirical Formula (Hill Notation):
C6H3F3NNaO2S
Molecular Weight:
233.14
UNSPSC Code:
12352200
NACRES:
NA.22

Assay

≥95%

form

powder

reaction suitability

reaction type: C-C Bond Formation

mp

340 °C (dec)

Application

This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

Other Notes

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Articles

Willis Pyridinates for Palladium-Catalyzed Cross-Coupling Reactions

Description: Professor Willis and partners at Pfizer have shown with pyridine-2- sulfinates a palladium-catalyzed desulfinylative cross-coupling process can be realized.

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Willis Group – Professor Product Portal

Research in the Willis group is focused on the development of new catalysts and reactions for synthetic chemistry. The group is particularly interested in addressing synthetic challenges that are applicable to the pharmaceutical and agrochemical industries.

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