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Sigma-Aldrich

PEGA resin

extent of labeling: ~0.4 mmol/g loading

Synonym(s):

Poly[acryloyl-bis(aminopropyl)polyethylene glycol]

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About This Item

MDL number:
MFCD00165212
UNSPSC Code:
12352200
NACRES:
NA.22

product line

PEGA

Quality Level

100

form

crystals

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

extent of labeling

~0.4 mmol/g loading

impurities

90% methanol

particle size

150-300 μm

functional group

amine

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General description

PEGA resins are a hydrophilic acrylamide-PEG co-polymer providing a really extensive and more uniform swelling in a wide range of solvents (from water, methanol, ethanol to tetrahydrofuran, acetonitrile and toluene). The extreme swelling volume of this support in the standard peptide synthesis solvents DCM and DMF together with their good stability make them ideally suited for the batch as well as for continuous-flow syntheses.

Application

Polyacrylamide resin possessing long polyethylene glycol spacers giving extremely high swell resin may be used for:
  • immobilizing enzymes in aqueous solution
  • affinity purification of small-molecule binding proteins
  • synthesis of peptide libraries with fluorescently labeled proteins

Packaging

Sold on basis of weight of dry resin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification of small molecule binding molecules by affinity purification using a specific ligand immobilized on PEGA resin.
Kuramochi K, et al.
Bioconjugate Chemistry, 19(12), 2417-2426 (2008)
A PEGA resin for use in the solid-phase chemical?enzymatic synthesis of glycopeptides.
Meldal M, et al.
Journal of the Chemical Society. Chemical Communications, 16, 1849-1850 (1994)
Synthesis, characterization and biocompatibility of PEGA resins.
Auzanneau FI, et al.
Journal of Peptide Science, 1(1), 31-44 (1995)
Chemical ligation of unprotected peptides directly from a solid support.
Camarero JA, et al.
The Journal of Peptide Research, 51(4), 303-316 (1998)
Catch and release of concanavalin A by a mannose-immobilized photoaffinity PEGA resin coupled with a cleavable disulfide linker.
Kuramochi K, et al.
Bioscience, Biotechnology, and Biochemistry, 79(12), 1946-1953 (2015)
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Related Content

Acrylamide-PEG Co-polymer (“PEGA”) Resin

The high swelling volume of PEGA resins makes the functionalities located within the polymer bead accessible to large biomolecules.

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