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1642201

USP

Sumatriptan-Succinat

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

3-[2-(Dimethylamino)-ethyl]-N-methyl-1H-indol-5-methansulfonamid-succinat, GR-43175

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About This Item

Empirische Formel (Hill-System):
C14H21N3O2S · C4H6O4
CAS-Nummer:
103628-48-4
Molekulargewicht:
413.49
MDL-Nummer:
MFCD00902856
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329751213
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

sumatriptan

Hersteller/Markenname

USP

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

−20°C

SMILES String

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChIKey

PORMUFZNYQJOEI-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1B(3351) , HTR1D(3352)

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Verwandte Kategorien

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Sumatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem./physiol. Wirkung

Sumatriptan-succinat ist ein Serotonin 5-HT1-Rezeptor-Agonist.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H361d - H412

Gefahreneinstufungen

Aquatic Chronic 3 - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Gallussäure certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

91215

Gallussäure

Triethylamin -hydrochlorid ≥99.0% (AT)

Sigma-Aldrich

90350

Triethylamin -hydrochlorid

Xiaojuan Wang et al.
Journal of molecular neuroscience : MN, 54(2), 164-170 (2014-03-04)
Neurogenic dural vasodilation has been demonstrated to play an important role in migraine. 5-HT(7) receptors have been found on trigeminal nerve endings and middle meningeal arteries and demonstrated involved in the dilatation of meningeal arteries. The aim of the present
Luana Lionetto et al.
Expert opinion on pharmacotherapy, 13(16), 2369-2380 (2012-09-28)
Migraine is a common neurovascular disorder characterized by recurrent episodes of disabling headache, autonomic nervous system dysfunction, and in some patients, neurological aura symptoms. Triptans are frequently prescribed drugs for the treatment of the acute migraine attack, considering their capability
Y Iwasawa et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 117(6), 387-393 (2001-07-05)
Sumatriptan succinate (SMT) was a highly specific 5-HT1-receptor agonist. It showed high affinity only for 5-HT but no affinity for other neurotransmitter receptors such as muscarinic, dopamine D1, D2, adrenergic alpha 1, alpha 2, and beta. Furthermore, it was highly
Dalapathi Gugulothu et al.
Drug development and industrial pharmacy, 41(3), 398-405 (2014-01-05)
The present investigation is aimed at development and characterization of sumatriptan succinate orodispersible tablets (ODTs) prepared by freeze drying technology. The tablet excipients were screened and the composition was optimized based on parameters which involved general appearance, tablet size and
Jessica L Knittel et al.
Journal of analytical toxicology, 39(1), 75-79 (2014-10-18)
A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT(1B/1D) receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No

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