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USP

Hydroxychloroquin -sulfat

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Hydroxychloroquinsulfat -sulfat, 7-Chlor-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]chinolinsulfat

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About This Item

Empirische Formel (Hill-System):
C18H26ClN3O · H2SO4
CAS-Nummer:
747-36-4
Molekulargewicht:
433.95
EG-Nummer:
212-019-3
MDL-Nummer:
MFCD00078203
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329750122
NACRES:
NA.24

Biologische Quelle

synthetic

Qualität

pharmaceutical primary standard

Agentur

USP

API-Familie

hydroxychloroquine

Verpackung

pkg of 200 mg

Hersteller/Markenname

USP

Lagerbedingungen

protect from light

Farbe

white to off-white

pH-Wert

3.5-5.5 (1% in aqueous solution, pH <6.0)

mp (Schmelzpunkt)

388.4 °F (198°C; 240°C)

Löslichkeit

chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChIKey

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Angaben zum Gen

human ... TLR7(51284) , TLR9(54106)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

Anwendung

Hydroxychloroquine sulfate USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard and system suitability solutions for assay, impurity analysis, and performance test, according to the given below monographs of United States Pharmacopeia (USP):
  • Hydroxychloroquine Sulfate Tablets
  • Hydroxychloroquine Sulfate
  • Chloroquine Phosphate

Biochem./physiol. Wirkung

Hydroxychloroquinsulfat ist ein entzündungshemmendes (über TNF), krankheitsmodifizierendes Antirheumatikum (DMARD) und ein Hemmstoff der Hämpolymerase. Es wird bei der Behandlung von Malaria eingesetzt.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Lys05 &#8805;98% (HPLC)

Sigma-Aldrich

SML2097

Lys05

2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol

Sigma-Aldrich

TMT00427

2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol

vibrant-m

C1650000

Chloroquinsulfat

Hydroxychloroquinsulfat -sulfat European Pharmacopoeia (EP) Reference Standard

Y0001839

Hydroxychloroquinsulfat -sulfat

Autophinib &#8805;98% (HPLC)

Sigma-Aldrich

SML2632

Autophinib

Chloroquin-verwandte Verbindung&nbsp;A United States Pharmacopeia (USP) Reference Standard

USP

1118328

Chloroquin-verwandte Verbindung A

Supelco

Supelco

PHR1734

Ritonavir

Spautin-1, Calbiochem A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC&#8325;&#8320; = 580 nM) and USP 13 (IC&#8325;&#8320; = 690 nM) deubiquitinating enzymes

Sigma-Aldrich

567569

Spautin-1, Calbiochem

Supelco

Supelco

PHR1927

Lopinavir

Chloroquin-verwandte Verbindung&nbsp;D United States Pharmacopeia (USP) Reference Standard

USP

1118350

Chloroquin-verwandte Verbindung D

Chloroquine Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Hydroxychloroquine Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2) (2021)
Daniel H Solomon et al.
Arthritis care & research, 66(8), 1246-1251 (2014-01-29)
Observational studies suggest that hydroxychloroquine (HCQ) may reduce the risk of developing diabetes mellitus in patients with rheumatoid arthritis (RA). We examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA. Twenty-three RA subjects
Jacques-Eric Gottenberg et al.
JAMA, 312(3), 249-258 (2014-07-17)
Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited. To evaluate the efficacy of hydroxychloroquine
Sandhya C Nair et al.
Arthritis care & research, 66(7), 998-1007 (2014-01-01)
Pragmatic clinical trials have been proposed as a solution for nongeneralizability of randomized clinical trial (RCT) results. We investigated whether treatment effects of pragmatic clinical trials are indeed generalizable to clinical practice and how efficacy estimates from published RCTs can
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Protokolle

Chloroquine Phosphate HPLC Assay and Impurity Profiling Methods Following the USP Monograph

Under applied conditions, system suitability criteria are met, and the Chloroquine Phosphate HPLC Assay and Impurity Profiling Methods demonstrate good resolution/selectivity, reproducibility, and sensitivity.

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