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SAB4501063

Sigma-Aldrich

Anti-GABBR1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

γ-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABBR1, Gb1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 108 kDa

Speziesreaktivität

mouse, human, rat

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

Q9UBS5

UniProt-Hinterlegungsnummer

Q9UBS5

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GABBR1(2550)

Verwandte Kategorien

Allgemeine Beschreibung

Anti-GABBR1 Antibody detects endogenous levels of total GABBR1 protein.
The γ-aminobutyric acid type B (GABAB) receptor is coded by the GABBR1 gene. It has 22 exons and spans at least 18 kb. GABAB geneis present between an olfactory receptor gene cluster downstream and the HLA (human leukocyte antigen) class I region upstream. It is mapped to human chromosome 6p22.

Immunogen

The antiserum was produced against synthesized peptide derived from human GABBR1.

Immunogen Range: 891-940

Biochem./physiol. Wirkung

The γ-aminobutyric acid type B (GABAB) is essential for the initiation by agonists like GABA (gamma-aminobutyric acid ). GABAB receptors participates in response habituation. In the visual cortex, GABAB is also involved in the initiation of orientation tuning in conjunction with GABAA receptors.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

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Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

GABBR1 has a HERV-W LTR in its regulatory region?a possible implication for schizophrenia.
Hegyi H.
Biology Direct, 8(1), 5-5 (2013)
Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population.
Li Z, et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 25(6), 517-524 (2016)
Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus.
Binns KE and Salt TE
The Journal of Physiology, 504(3), 629-639 (1997)
GABBR 1 and SLC 6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Enoch MA, et al.
Alcoholism, Clinical and Experimental Research, 40(1), 93-101 (2016)

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