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SAB4200179

Sigma-Aldrich

Anti-Importin 5 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(e):

Anti-IPO5

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~123 kDa

Speziesreaktivität

human

Konzentration

~1.0 mg/mL

Methode(n)

immunoprecipitation (IP): 2.5-5.0 μg using lysates of human HEK-293 cells.
indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293 cells overexpressing human Importin 5.
western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.

UniProt-Hinterlegungsnummer

O00410

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IPO5(3843)
mouse ... Ipo5(70572)
rat ... Ipo5(306182)

Verwandte Kategorien

Allgemeine Beschreibung

In human cells, there are more than 20 members of the importins/exportins family. Importin-5 (IPO5) belongs to the importin-β superfamily and is mapped to human chromosome 13q32.2.

Anwendung

Anti-Importin 5 (C-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem./physiol. Wirkung

Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins are regulated by the Ran G protein. Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Genome-wide association study of peripheral arterial disease in a Japanese population
Matsukura M, et al.
Testing, 10(10), e0139262-e0139262 (2015)
The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation
Clerman A, et al.
The Journal of biological chemistry, 292(52), 21653-21661 (2017)
Structural biology of nucleocytoplasmic transport
Cook A, et al.
Annual Review of Biochemistry, 76(3), 647-671 (2007)
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)
Pauline J van der Watt et al.
International journal of cancer, 150(2), 347-361 (2021-10-01)
Previous studies have identified increased expression of members of the nuclear transport protein family in cancer cells. Recently, certain nuclear transport proteins have been reported to be secreted by cells and found in the serum. The aims of our study

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