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Dokumente

P6004

Sigma-Aldrich

Prednisolon

≥99%

Synonym(e):

1,4-Pregnadien-11β,17α,21-triol-3,20-dion, 1-Dehydrocortisol, 1-Dehydrohydrocortison, 11β,17α,21-Trihydroxy-1,4-pregnadien-3,20-dion

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About This Item

Empirische Formel (Hill-System):
C21H28O5
CAS-Nummer:
50-24-8
Molekulargewicht:
360.44
Beilstein:
1354103
EG-Nummer:
200-021-7
MDL-Nummer:
MFCD00003649
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24898725

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Sterilität

non-sterile

Assay

≥99%

Form

powder

mp (Schmelzpunkt)

240 °C (dec.) (lit.)

Löslichkeit

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

Ersteller

Johnson & Johnson

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Angaben zum Gen

human ... AR(367) , ESR1(2099) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866)
mouse ... Nr3c1(14815)
rat ... Ar(24208)

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Allgemeine Beschreibung

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Anwendung

Prednisolone has been used for the Δ1-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Biochem./physiol. Wirkung

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Hinweis zur Analyse

Actual content given on label

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360FD

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Sigma-Aldrich

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Prednisolon 21-Acetat

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Supelco

PHR1042

Prednison

Kortison ≥95%

Sigma-Aldrich

C2755

Kortison

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Betamethason ≥98%

Sigma-Aldrich

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Betamethason

Prednison European Pharmacopoeia (EP) Reference Standard

P2900000

Prednison

Prednisolonhemisuccinat United States Pharmacopeia (USP) Reference Standard

USP

1556507

Prednisolonhemisuccinat

Continuous non-aerated Delta 1-dehydrogenation of hydrocortisone by PAAH-bead entrapped Arthrobacter simplex
Silbiger E and Freeman A
Applied Microbiology and Biotechnology, 29(5), 413-418 (1988)
H Schäcke et al.
British journal of pharmacology, 158(4), 1088-1103 (2009-05-09)
Glucocorticoids are highly effective in the therapy of inflammatory diseases. Their value, however, is limited by side effects. The discovery of the molecular mechanisms of the glucocorticoid receptor and the recognition that activation and repression of gene expression could be
Vivi M Heine et al.
Science translational medicine, 3(105), 105ra104-105ra104 (2011-10-21)
Glucocorticoids are used for treating preterm neonatal infants suffering from life-threatening lung, airway, and cardiovascular conditions. However, several studies have raised concerns about detrimental effects of postnatal glucocorticoid administration on the developing brain leading to cognitive impairment, cerebral palsy, and
Shin Ebihara et al.
Arthritis research & therapy, 18(1), 139-139 (2016-06-16)
Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the anti-inflammatory effects of Nrf2 activators on human renal
Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle
Wehling-Henricks M, et al.
Neuromuscular Disorders, 14(8-9), 483-490 (2004)
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