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O5500

Sigma-Aldrich

Osmiumtetroxid

Sealed ampule.

Synonym(e):

Osmium(VIII)-oxid, ‘Osmiumsäure’

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About This Item

Lineare Formel:
OsO4
CAS-Nummer:
20816-12-0
Molekulargewicht:
254.23
EG-Nummer:
244-058-7
MDL-Nummer:
MFCD00011150
UNSPSC-Code:
12171500
PubChem Substanz-ID:
57654490
NACRES:
NA.47

Dampfdichte

8.8 (vs air)

Qualitätsniveau

200

Dampfdruck

7 mmHg ( 20 °C)

Form

powder

Eignung der Reaktion

reagent type: oxidant

bp

130 °C (lit.)

mp (Schmelzpunkt)

39.5-41 °C (lit.)

SMILES String

O=[Os](=O)(=O)=O

InChI

1S/4O.Os

InChIKey

VUVGYHUDAICLFK-UHFFFAOYSA-N

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Allgemeine Beschreibung

Osmium tetroxide (OsO4) is a heavy tetrahedral, symmetrical molecule composed of osmium, a third-row transition metal. Osmium tetroxide is both a dye, and a non-coagulant fixative agent in electron microscopy primarily used for the examination of biological tissue components in the histopathology laboratory. Specimens are postfixed with osmium testroxide to ensure preservation of the lipids.

Anwendung

Osmium tetroxide has been used as a fixative reagent for Brevibacterium mcbrellneri, and curcumin treated human lung cancer cell lines′ observation with a scanning electron microscope. It is also suitable as a fixative for ultrastructural analysis of Toxoplasma gondii′s skeletal muscle cells.

Biochem./physiol. Wirkung

Osmium tetroxide chemically combines with lipids making them insoluble; only 7% of the lipids can be extracted after the fixation. Therefore, the cell membranes comprising phospholipids become black and electron-dense after fixation in osmium tetroxide. It is also used to fix small amount of fat maintained in sections during paraffin processing.

Sonstige Hinweise

Due to the hazardous nature of osmium tetroxide, it is recommended to use an ampule opener when using this chemical.

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Z693847

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Piktogramme

CorrosionSkull and crossbones
GHS05,GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1B

Lagerklassenschlüssel

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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