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N9891

Sigma-Aldrich

Monoclonal Anti-Nebulin antibody produced in mouse

clone NB2, ascites fluid

Synonym(e):

Anti-AMC6, Anti-NEB177D, Anti-NEM2

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About This Item

MDL-Nummer:
MFCD00164706
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

NB2, monoclonal

Mol-Gew.

antigen 500 kDa

Enthält

15 mM sodium azide

Speziesreaktivität

vertebrates, chicken

Methode(n)

indirect immunofluorescence: 1:400 using frozen sections of animal skeletal muscle
western blot: suitable

Isotyp

IgG1

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

chicken ... NEB(101748402)

Verwandte Kategorien

Allgemeine Beschreibung

Nebulin is a 700kDa protein which is expressed in skeletal muscles. It possesses 35 amino acid repeats and a C terminal serine-rich and SH3 domains.
Nebulin is also localized to cardiac muscle. Monoclonal Anti-Nebulin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Spezifität

Localizes nebulin in skeletal muscle of a wide variety of species from cold-blooded vertebrates to man. Does not crossreact with smooth or cardiac muscle, non-muscle tissue and cultured cells. Localizes nebulin within the I band of skeletal muscle sections by indirect immunofluorescence.

Immunogen

chicken breast nebulin.

Anwendung

Monoclonal Anti-Nebulin antibody produced in mouse has been used in:
  • immunohistochemistry
  • fluorescent immunostaining
  • western blotting

Biochem./physiol. Wirkung

Nebulin associates with the Z-line and thin actin filament in a sarcomere. It may function as a regulator of sarcomere thin filament length. The protein also acts as a structural link between sarcomeres. Nebulin interacts with the capping protein CapZ and has a role in controlling the localization of actin filaments.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

A 7.5-kb 3'-Terminal cDNA Sequence of Chicken Skeletal Muscle Nebulin Reveals Its Actin Binding Regions.
Suzuki T
Zoological Science (2000)
Identification of chicken nebulin isoforms of the 31-residue motifs and non-muscle nebulin.
Joo YM
Biochemical and Biophysical Research Communications (2004)
James D Morton et al.
Meat science, 143, 129-136 (2018-05-12)
High pressure processing (HPP) of pre-rigor longissimus thoracis (strip loin) from prime and bull animals substantially decreased the shear force and improved consumer eating attributes of the final meat product. The improved tenderness in both prime and bull meat was
Clinical phenotype, muscle MRI and muscle pathology of LGMD1F
Peterle E, et al.
Journal of Neurology, 260(8), 2033-2041 (2013)
Clinical phenotype, muscle MRI and muscle pathology
of LGMD1F
Enrico Peterle
Journal of Neurology (2013)
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