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Dokumente

M6699

Sigma-Aldrich

Maslinsäure

≥98% (HPLC)

Synonym(e):

2α,3β-Dihydroxy-12-oleanen-28-säure, 2α-Hydroxy-oleanolsäure, Crategolsäure

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About This Item

Empirische Formel (Hill-System):
C30H48O4
CAS-Nummer:
4373-41-5
Molekulargewicht:
472.70
MDL-Nummer:
MFCD00049293
UNSPSC-Code:
12352205
PubChem Substanz-ID:
329818034
NACRES:
NA.25

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

acetone: 1 mg/mL, clear, colorless

Anwendung(en)

metabolomics
vitamins, nutraceuticals, and natural products

Lagertemp.

2-8°C

SMILES String

CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O

InChI

1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1

InChIKey

MDZKJHQSJHYOHJ-LLICELPBSA-N

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Allgemeine Beschreibung

Maslinic acid is a pentacyclic triterpene compound first isolated from Crataegus oxyacantha L. It is primarily sourced from Olea europaea L. and can be found in the non-glyceride fraction of olive pomace.

Anwendung

Maslinic acid has been used to study its antiproliferative and antiangiogenic effects on human renal cell carcinoma (RCC) cell lines and endothelial cells, respectively. It has also been used as a reference standard to extract triterpenoic acids from olive pomace using the microwave-assisted extraction (MAE) method.

Biochem./physiol. Wirkung

Maslinic acid is a potent antioxidant and anti-inflammatory agent. Other than being an excellent anti-cancer agent, it also displays anti-diabetic, and anti-parasitic properties. Maslinic acid exerts neuroprotective and cardioprotective effects. It has been reported to be a multi-targeted antimalarial drug against Plasmodium falciparum.
Predominant triterpenoid found in olives. Anti-proliferative. Promising chemopreventive agent.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Ursolsäure analytical standard

Supelco

89797

Ursolsäure

Ursolsäure ≥90%

Sigma-Aldrich

U6753

Ursolsäure

Uvaol ≥95%

Sigma-Aldrich

U6628

Uvaol

Hederagenin ≥97% (HPLC)

Sigma-Aldrich

H3916

Hederagenin

Asiatsäure 97%

Sigma-Aldrich

546712

Asiatsäure

Erythrodiol analytical standard

Supelco

09258

Erythrodiol

Betulinsäure ≥98% (HPLC)

Sigma-Aldrich

B8936

Betulinsäure

Anacardinsäure

Sigma-Aldrich

A7236

Anacardinsäure

Parth Thakor et al.
Journal of kidney cancer and VHL, 4(1), 16-24 (2017-04-14)
Despite the introduction of many novel therapeutics in clinical practice, metastatic renal cell carcinoma (RCC) remains a treatment-resistant cancer. As red and processed meat are considered risk factors for RCC, and a vegetable-rich diet is thought to reduce this risk
Glòria Lozano-Mena et al.
Journal of agricultural and food chemistry, 60(41), 10220-10225 (2012-09-26)
Maslinic acid, a pentacyclic triterpene from olives, has been reported to exert beneficial effects on health, including anticarcinogenic activity. Despite its importance, little is known about its bioavailability in both humans and animals. A fundamental step for this evaluation consisted
Carlos Moneriz et al.
The FEBS journal, 278(16), 2951-2961 (2011-06-22)
Most drugs against malaria that are available or under development target a single process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments. Maslinic acid (MA) is a low
Yisong Qian et al.
European journal of pharmacology, 670(1), 148-153 (2011-08-16)
Maslinic acid is a triterpenoid compound present in plants of Olea europaea. This compound has been reported to have potent antioxidant, anti-cancer, anti-HIV and anti-inflammatory activities. In this study, we investigated the neuroprotective effect of maslinic acid and its mechanism
Susana Sánchez-Tena et al.
PloS one, 8(3), e59392-e59392 (2013-03-26)
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known
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