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Merck

M3808

Sigma-Aldrich

MRS 2179 ammonium salt hydrate

≥98% (HPLC)

Synonym(e):

2′-Deoxy-N6-methyl adenosine 3′,5′-diphosphate diammonium salt

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About This Item

Empirische Formel (Hill-System):
C11H17N5O9P2 · xNH3 · yH2O
CAS-Nummer:
Molekulargewicht:
425.23 (anhydrous free acid basis)
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥98% (HPLC)

Lagerbedingungen

desiccated

Löslichkeit

DMSO: 1.1 mg/mL
H2O: >10 mg/mL

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

N.O.CNc1ncnc2n(cnc12)[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3

InChI

1S/C11H17N5O9P2.H3N.H2O/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19;;/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22);1H3;1H2/t6-,7+,8+;;/m0../s1

InChIKey

DEQIORFOBOEGKZ-ZJWYQBPBSA-N

Angaben zum Gen

human ... P2RY1(5028)

Anwendung

MRS 2179 ammonium salt hydrate has been used as a P2Y1 receptor antagonist in porcine coronary small arteries, endothelial cells, and hippocampal astrocytes.

Biochem./physiol. Wirkung

MRS 2179 resists localized venous thrombosis and is useful in treating thrombotic syndromes due to its platelet aggregation inhibition functionality.
Competitive P2Y1 purinoceptor antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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A Baurand et al.
European journal of pharmacology, 412(3), 213-221 (2001-02-13)
The effects of a potent P2Y1 receptor antagonist, N6-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179) on adenosine-5'-diphosphate (ADP)-induced platelet aggregation in vitro, ex vivo and on the bleeding time in vivo were determined. In suspensions of washed platelets, MRS2179 inhibited ADP-induced platelet shape change, aggregation
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