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H3160

Sigma-Aldrich

Hydrocortison

meets USP testing specifications

Synonym(e):

11β,17α,21-Trihydroxypregn-4-en-3,20-dion, 17-Hydroxykortikosteron, 4-Pregnen-11β,17α,21-triol-3,20-dion, Cortisol, Kendall’s Compound F, Reichstein’s Substance M

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About This Item

Empirische Formel (Hill-System):
C21H30O5
CAS-Nummer:
50-23-7
Molekulargewicht:
362.46
Beilstein:
1354819
EG-Nummer:
200-020-1
MDL-Nummer:
MFCD00011654
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24895560
NACRES:
NA.21

Biologische Quelle

plant (wild yam)

Qualitätsniveau

300

Agentur

USP/NF
meets USP testing specifications

Assay

97.0-102.0% dry basis

Form

powder

Wirksamkeit

0.004-0.005 μg/mL

mp (Schmelzpunkt)

211-214 °C (lit.)

Löslichkeit

water: soluble 0.28 g/L at 25 °C

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

JYGXADMDTFJGBT-VWUMJDOOSA-N

Angaben zum Gen

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

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Verwandte Kategorien

Anwendung


  • Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).

  • Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).

Biochem./physiol. Wirkung

Primäres Glucocorticoid im Sekret der Nebennierenrinde. Hat ein dreimal so hohes entzündungshemmendes Potential wie Corticosteron bei einem deutlich geringeren Potential zur Na2+-Retention.

Physikalische Form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Piktogramme

Health hazard
GHS08

Signalwort

Danger

Gefahreneinstufungen

Repr. 1A - STOT RE 2

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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Hydrocortison Steroid hormone of the adrenal cortex with anti-inflammatory properties.

Sigma-Aldrich

3867

Hydrocortison

Hydrocortison-9,11,12,12-d4 ≥98 atom % D, ≥98% (CP)

Sigma-Aldrich

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Cortisol-D4 (9,11,12,12-D4) -Lösung 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

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Hydrocortison-Acetat Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

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Hydrocortison-Acetat

Kortison ≥95%

Sigma-Aldrich

C2755

Kortison

Corticosteron ≥98.5% (HPLC)

Sigma-Aldrich

27840

Corticosteron

Margriet A B Veldhorst et al.
The Journal of clinical endocrinology and metabolism, 99(1), 285-290 (2014-01-05)
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
Lorenz Goette et al.
Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
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