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Dokumente

G117

Sigma-Aldrich

Glipizid

solid

Synonym(e):

1-Cyclohexyl-3-{4-[2-(5-methylpyrazin-2-carboxamido)-ethyl]-phenylsulfonyl}-harnstoff

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About This Item

Empirische Formel (Hill-System):
C21H27N5O4S
CAS-Nummer:
29094-61-9
Molekulargewicht:
445.54
EG-Nummer:
249-427-6
MDL-Nummer:
MFCD00072159
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277839

Form

solid

Qualitätsniveau

100

Farbe

white

Löslichkeit

methanol: 1.9 mg/mL
DMSO: 48 mg/mL

SMILES String

Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

InChIKey

ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Angaben zum Gen

human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

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Allgemeine Beschreibung

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Anwendung

Glipizide has been used in:
  • chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
  • MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
  • metastasis assays
  • rat aortic ring assay
  • in vivo matrigel plug assay
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
  • flow cytometry
  • western blotting

Biochem./physiol. Wirkung

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K+ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Glybenclamid ≥99% (HPLC)

Sigma-Aldrich

G0639

Glybenclamid

USP

USP

1353000

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Tolbutamid analytical standard

Supelco

T0891

Tolbutamid

Clemastine fumarate salt ≥98% (HPLC)

Sigma-Aldrich

SML0445

Clemastine fumarate salt

Pioglitazone

Sigma-Aldrich

CDS021593

Pioglitazone

Glimepiride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1617

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Daidzin ≥95.0% (HPLC)

Sigma-Aldrich

30408

Daidzin

Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis
Qi C, et al.
Scientific reports, 6(20), 27819-27819 (2016)
KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinoma
Guo Z, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 36(2), 1251-1259 (2015)
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment
Karnes JH, et al.
The Pharmacogenomics Journal, 13(5), 430-430 (2013)
K M Pantalone et al.
Diabetes, obesity & metabolism, 14(9), 803-809 (2012-04-11)
It remains uncertain if differences in mortality risk exist among the sulfonylureas, especially in patients with documented coronary artery disease (CAD). The purpose of this study was to assess the overall mortality risk of the individual sulfonylureas versus metformin in
Greg L Plosker
Drugs, 72(17), 2289-2312 (2012-11-23)
Dapagliflozin (Forxiga®) is the first in a novel class of glucose-lowering agents known as sodium-glucose co-transporter-2 (SGLT2) inhibitors and is used in the treatment of patients with type 2 diabetes. By inhibiting the transporter protein SGLT2 in the kidneys, dapagliflozin
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