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F5006

Sigma-Aldrich

2-Fluor-2-Desoxy-D-Glucose

glycosylation inhibitor, glucose analog

Synonym(e):

2-Deoxy-2-fluor-D-glucose, FDG

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About This Item

Empirische Formel (Hill-System):
C6H11FO5
CAS-Nummer:
29702-43-0
Molekulargewicht:
182.15
MDL-Nummer:
MFCD00077527
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24894876

Qualitätsniveau

300

Lagertemp.

2-8°C

SMILES String

OCC1OC(O)C(F)C(O)C1O

InChI

1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2

InChIKey

ZCXUVYAZINUVJD-UHFFFAOYSA-N

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Allgemeine Beschreibung

2-Fluoro-2-deoxy-D-glucose is non-toxic and a structural analog of glucose, significantly inhibiting glycosylation. As a glucose analog, uptake of 2-Fluoro-2-deoxy-D-glucose is rapid in brain and heart cells.

2-Fluoro-2-deoxy-D-glucose can be taken up by cells but does not undergo metabolic glycolysis.

Anwendung

2-Fluoro-2-deoxy-D-glucose is used as a tracer for rapid tumor detection. It is used as a glucose analog to study glucose uptake in mice with radiation and burn injuries. Oncology therapy studies use FDG in combination with PET (Positron Emission Topography)

Biochem./physiol. Wirkung

Glucose analog that inhibits cellular glycosylation.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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Verwandter Inhalt

Stable Isotopes in PET (Positron Emission Tomography)

Labeled isotopes used as target materials in imaging have provided insights into the various mechanisms of human physiology and have lead to treatments for diseases. Water-18O is used for the production of 18F radionuclides, such as 18FDG (Fluoro-deoxyglucose). 18FDG used in PET and with other imaging technologies, such as CT/SPECT, has led to the diagnosis and treatment of a wide range of diseases, including lung, liver, and brain tumors, epilepsy, and Alzheimer’s.

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