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C7897

Sigma-Aldrich

Clonidin -hydrochlorid

solid

Synonym(e):

2-(2,6-Dichloranilino)-2-imidazolin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C9H9Cl2N3 · HCl
CAS-Nummer:
4205-91-8
Molekulargewicht:
266.55
Beilstein:
4163525
EG-Nummer:
224-121-5
MDL-Nummer:
MFCD00036705
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277750
NACRES:
NA.77

Form

solid

Qualitätsniveau

100

Farbe

white

Löslichkeit

H2O: soluble
methanol: soluble

Ersteller

Boehringer Ingelheim

Lagertemp.

2-8°C

SMILES String

Cl[H].Clc1cccc(Cl)c1NC2=NCCN2

InChI

1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

InChIKey

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Allgemeine Beschreibung

Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.

Anwendung

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:
  • in ex vivo leptin release assay
  • to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
  • to study its influence on the sleep of larval zebrafish
  • to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation

Clonidine hydrochloride has been used:
  • to reduce central noradrenaline levels
  • to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
  • to attenuate thermal and mechanical pain hypersensitivity in rats
  • as a positive control for pertussis toxin (PTX)

Biochem./physiol. Wirkung

α2-adrenoceptor agonist; I1 imidazoline binding site ligand.
Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.

Leistungsmerkmale und Vorteile

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301 - H330

Gefahreneinstufungen

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Sigma-Aldrich

Sigma-Aldrich

SML0956

Dexmedetomidin -hydrochlorid

USP

USP

1140418

Clonidin-verwandte Verbindung A

Idazoxan hydrochloride

Sigma-Aldrich

I6138

Idazoxan hydrochloride

N-(2-Chlorethyl)-N-Ethyl-2-Brombenzylamin -hydrochlorid ≥98%, solid

Sigma-Aldrich

C8417

N-(2-Chlorethyl)-N-Ethyl-2-Brombenzylamin -hydrochlorid

Phentolamin -hydrochlorid ≥98% (TLC), powder

Sigma-Aldrich

P7547

Phentolamin -hydrochlorid

Methoxamin -hydrochlorid

Sigma-Aldrich

M6524

Methoxamin -hydrochlorid

Safety and efficacy of clonidine and clonidine extended-release in the treatment of children and adolescents with attention deficit and hyperactivity disorders
Ming X, et al.
Adolescent health, medicine and therapeutics, 2(2), 105-105 (2011)
INT-005 Development and stability testing of oral clonidine hydrochloride solutions for use in neonatal patients
Buttner B, et al.
European Journal of Hospital Pharmacy (2017)
Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective
Gentili M, et al.
British journal of anaesthesia, 79(5), 660-661 (1997)
Z P Khan et al.
Anaesthesia, 54(2), 146-165 (1999-04-24)
Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have
Evaluation of clonidine hydrochloride (Catapres): a new antihypertensive agent
Kosman ME
JAMA : The Journal of the American Medical Association, 233(2), 174-176 (1975)
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