Direkt zum Inhalt
Merck
Alle Fotos(3)

Dokumente

C4282

Sigma-Aldrich

Coenzym A Hydrat

≥85% (UV, HPLC)

Synonym(e):

CoA

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(3)

About This Item

Empirische Formel (Hill-System):
C21H36N7O16P3S · xH2O
CAS-Nummer:
85-61-0
Molekulargewicht:
767.53 (anhydrous basis)
Beilstein:
77809
MDL-Nummer:
MFCD06795839
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24892684
NACRES:
NA.21

Biologische Quelle

yeast

Qualitätsniveau

200

Assay

≥85% (UV, HPLC)

Form

powder

Funktionelle Gruppe

phospholipid

Versandbedingung

ambient

Lagertemp.

−20°C

SMILES String

O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS

InChI

1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1

InChIKey

TVSAELAFGDOPKI-BLPRJPCASA-N

Verwandte Kategorien

Anwendung

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Biochem./physiol. Wirkung

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. CoA plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

Vorsicht

The free acid is less stable than the sodium or lithium salt; 5% decomposition may occur within 6 months when stored at −80 °C.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 8

1 of 8

Avanti Polar Lipids 870701P, powder

Avanti

870701P

Coenzyme A (Li salt)

Malonyl-Coenzym A ≥90% (HPLC)

Sigma-Aldrich

M4263

Malonyl-Coenzym A

D-(−)-3-Phosphoglycerinsäure Dinatriumsalz ≥93% dry basis (enzymatic), powder

Sigma-Aldrich

P8877

D-(−)-3-Phosphoglycerinsäure Dinatriumsalz

Palmitoyl-Coenzym A Lithiumsalz ≥90%

Sigma-Aldrich

P9716

Palmitoyl-Coenzym A Lithiumsalz

Butyryl-Coenzym A Lithiumsalz Hydrat ≥90%

Sigma-Aldrich

B1508

Butyryl-Coenzym A Lithiumsalz Hydrat

3′-Dephosphocoenzym A ≥90% (HPLC)

Sigma-Aldrich

D3385

3′-Dephosphocoenzym A

≥90%

Sigma-Aldrich

B1638

Benzoyl coenzyme A lithium salt

Thiaminpyrophosphat ≥95%

Sigma-Aldrich

C8754

Thiaminpyrophosphat

Takuya Ishibashi et al.
Extremophiles : life under extreme conditions, 16(6), 819-828 (2012-09-04)
We have previously reported that the majority of the archaea utilize a novel pathway for coenzyme A biosynthesis (CoA). Bacteria/eukaryotes commonly use pantothenate synthetase and pantothenate kinase to convert pantoate to 4'-phosphopantothenate. However, in the hyperthermophilic archaeon Thermococcus kodakarensis, two
Francis McCoy et al.
Molecular cell, 52(3), 325-339 (2013-10-08)
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus
Johannes Holert et al.
Journal of bacteriology, 195(3), 585-595 (2012-12-04)
Bacterial degradation of steroids is widespread, but the metabolic pathways have rarely been explored. Previous studies with Pseudomonas sp. strain Chol1 and the C(24) steroid cholate have shown that cholate degradation proceeds via oxidation of the A ring, followed by
Clonorchis sinensis acetoacetyl-CoA thiolase: identification and characterization of its potential role in surviving in the bile duct
Lin J, et al.
Parasites & vectors, 8(1), 125-125 (2015)
John C Newman et al.
The Journal of biological chemistry, 287(51), 42436-42443 (2012-10-23)
The sirtuins are a family of NAD(+)-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. Three sirtuins, SIRT3-5, localize to mitochondria. Expression of SIRT3 is selectively activated during fasting and calorie restriction. SIRT3 regulates the acetylation level and enzymatic
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.