B3648
Monoklonaler Anti-Human IgG4
clone HP-6025, purified from hybridoma cell culture
Synonym(e):
Monoclonal Anti-Human IgG4
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.46
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
biotin conjugate
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
secondary antibodies
Klon
HP-6025, monoclonal
Form
buffered aqueous solution
Speziesreaktivität
human
Methode(n)
direct ELISA: 1:60,000
Isotyp
IgG1
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
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Spezifität
Monoklonaler Anti-Human IgG4 ist spezifisch für die IgG4-Unterklasse und nicht reaktiv mit IgG1, IgG2 und IgG3 im ELISA.
Anwendung
In der IUIS/WHO2 Studie wurde dieser monoklonale Antikörper als einer der am vielseitigsten einsetzbare IgG4-spezifische monoklonale Antikörper hervorgehoben. Monoklonaler Anti-Human-IgG4 kann für die Identifizierung der IgG4-Unterklasse durch verschiedene Immunoassays verwendet werden, darunter: ELISA, Imprint-Immunfixation (IIF), Immunfluorometrischer Assay (IFMA), Hämagglutination (HA), Hämagglutination-Hemmung (HAI), Particle Counting Immunoassay (PACIA) und Detektion von cytoplasmischen IgG.
Anti-Human IgG4−Biotin antibody, Mouse monoclonal has been used in immunohistochemistry and immunostaining.
Monoclonal Anti-Human IgG4-Biotin antibody produced in mouse may be used in ELISA at a working dilution of 1:15,000. It was used for detection of serum IgG4 produced in response to malaria parasite infection by ELISA.
Biochem./physiol. Wirkung
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. The coupling of biotin to monoclonal Anti-Human IgG4 antibody allows for the binding of various labels such as avidin or streptavidin.
IgG4 is the least abundant immunoglobulin present in the human serum. IgG4 is implicated in a unique process called fab-arm exchange (FAE) and limits the formation of immune complex. It has anti-inflammatory properties. IgG4 functions as a therapeutic antibody. It provides protection against allergy, prevents mast cell degranulation and has a harmful role in malignant melanoma. IgG4 may be associated with autoimmune diseases such as, autoimmune pancreatitis (AIP) type 1 and 2, Mikulicz syndrome, Kuttner′s tumor, Riedel′s thyroiditis and tubulointerstitial nephritis.
Physikalische Form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Murata Y, et al.
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A Nasr et al.
Scandinavian journal of immunology, 66(1), 87-96 (2007-06-26)
In a prospective clinical study in New Halfa Teaching Hospital, the possible association between FcgammaRIIa-R/H131 polymorphism and anti-malarial antibody responses with clinical outcome of Plasmodium falciparum malaria among Sudanese patients was investigated. A total of 256 individuals were consecutively enrolled
Hayder A Giha et al.
Malaria journal, 8, 306-306 (2009-12-24)
Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control. In this study, 216 individuals from Daraweesh
Hayder A Giha et al.
Vaccine, 28(7), 1732-1739 (2009-12-29)
The certainty of the protective role of acquired immunity in malaria is the major drive for malaria vaccine development. In this study, we measured the levels of total IgG and IgG subclasses to four candidate malaria vaccine antigens; MSP2-3D7, MSP2-FC27
Nnaemeka C Iriemenam et al.
Vaccine, 27(1), 62-71 (2008-11-04)
Despite many intervention programmes aimed at curtailing the scourge, malaria remains a formidable problem of human health. Immunity to asexual blood-stage of Plasmodium falciparum malaria is thought to be associated with protective antibodies of certain immunoglobulin classes and subclasses. We
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