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Dokumente

A8003

Sigma-Aldrich

Allopurinol

xanthine oxidase inhibitor

Synonym(e):

1H-Pyrazolo[3,4-d]pyrimidin-4-ol, 4-Hydroxypyrazolo[3,4-d]pyrimidin, HPP

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About This Item

Empirische Formel (Hill-System):
C5H4N4O
CAS-Nummer:
315-30-0
Molekulargewicht:
136.11
EG-Nummer:
206-250-9
MDL-Nummer:
MFCD00599413
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278141
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥99% (TLC)

Form

powder

mp (Schmelzpunkt)

>300 °C (lit.)

Löslichkeit

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

Lagertemp.

room temp

SMILES String

O=C1NC=Nc2[nH]ncc12

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

InChIKey

OFCNXPDARWKPPY-UHFFFAOYSA-N

Angaben zum Gen

human ... XDH(7498)

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Anwendung

Allopurinol has been used:
  • to decrease the uric acid levels and study its effect on renal injury and inflammation in mice
  • as a xanthine oxidase inhibitor to test panton-valentine leukocidin (PVL) neutrophil extracellular traps (NETosis) dependence on different enzymes, channels, or organelles using human polymorphonuclear cells (hPMNs)
  • as a reference standard to study the inhibitory effect of olive leaf components on xanthine oxidase in vitro

Allopurinol is suitable for:
  • intravenous injection in mice for inhibition of xanthine oxidase
  • use as an inhibitor of xanthine oxidase
  • use as a positive control in xanthine oxidase inhibition assay
  • use in the preparation of University of Wisconsin solution for osmotic stabilization to enhance the density differences between islets and acinar fragments during porcine islet purification

Biochem./physiol. Wirkung

Allopurinol is a purine analog that inhibits certain enzymes involved in purine metabolism. It is known to reduce the synthesis of uric acid in the body. Allopurinol mediated inhibition of xanthine oxidase exhibits anti-inflammatory effects on atherosclerosis, acute lung injury, and congestive heart failure.
Inhibitor von Xanthinoxidase und der de novo-Biosynthese von Pyrimidin. Ein klassisches Mittel bei der Behandlung von Hyperurikämie und Gicht.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301 - H317

Gefahreneinstufungen

Acute Tox. 3 Oral - Skin Sens. 1

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

X4376

Xanthinoxidase aus Kuhmilch

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Roche

10110434001

Xanthine Oxidase (XOD)

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Sigma-Aldrich

L2398

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Sigma-Aldrich

H1753

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Sigma-Aldrich

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Sigma-Aldrich

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Xanthinoxidase aus microbiell

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