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Dokumente

A6060

Sigma-Aldrich

Calpain-Inhibitor II

powder

Synonym(e):

N-Acetyl-L-leucyl-L-leucyl-L-methioninal

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About This Item

Empirische Formel (Hill-System):
C19H35N3O4S
CAS-Nummer:
110115-07-6
Molekulargewicht:
401.56
Beilstein:
7693643
MDL-Nummer:
MFCD00065506
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24891051
NACRES:
NA.77

Assay

≥95% (HPLC)

Qualitätsniveau

100

Form

powder

Farbe

white

Löslichkeit

ethanol: 20 mg/mL

Lagertemp.

−20°C

SMILES String

[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1

InChIKey

RJWLAIMXRBDUMH-ULQDDVLXSA-N

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Anwendung

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Biochem./physiol. Wirkung

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Sonstige Hinweise

Formerly CAS# 136632-32-1

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Calpain-Inhibitor VI The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208745

Calpain-Inhibitor VI

PD 150606 ≥97% (HPLC)

Sigma-Aldrich

D5946

PD 150606

Calpastatin-Peptid Ac 184–210 ≥95% (HPLC)

Sigma-Aldrich

SCP0063

Calpastatin-Peptid Ac 184–210

Cathepsin-Inhibitor I The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

219415

Cathepsin-Inhibitor I

Calpeptin A cell-permeable calpain inhibitor (ID₅₀ = 52 nM for calpain-1; ID₅₀ = 34 nM for calpain-2; ID₅₀ = 138 nM for papain).

Sigma-Aldrich

03-34-0051

Calpeptin

Antipain -dihydrochlorid aus microbieller Quelle protease inhibitor

Sigma-Aldrich

A6191

Antipain -dihydrochlorid aus microbieller Quelle

CA-074 ≥99% (TLC)

Sigma-Aldrich

C5732

CA-074

Keduo Qian et al.
Bioorganic & medicinal chemistry letters, 21(19), 5944-5947 (2011-08-23)
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibition of the chymotrypsin-like activity of 20S proteasome. From the SAR study, we concluded that the C-3 and C-30 positions are the pharmacophores for increasing
The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4
Al Sorkhy M, et al.
The Journal of Biological Chemistry, 284(5), 2617-2627 (2009)
Zhao Dang et al.
Bioorganic & medicinal chemistry letters, 21(7), 1926-1928 (2011-03-11)
A new class of proteasome inhibitors was synthesized using lithocholic acid as a scaffold. Modification at the C-3 position of lithocholic acid with a series of acid acyl groups yielded compounds with a range of potency on proteasome inhibition. Among
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova S, et al.
Epilepsy Research (2011)
Aneurysm: New Insights for the Healthcare Professional, 56-57 (2013)
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