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01897

Sigma-Aldrich

Adenosin-5′-diphosphat Dinatriumsalz

≥90%

Synonym(e):

5′-ADP-Na2

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About This Item

Empirische Formel (Hill-System):
C10H13N5Na2O10P2
CAS-Nummer:
16178-48-6
Molekulargewicht:
471.16
Beilstein:
7563620
EG-Nummer:
240-314-7
MDL-Nummer:
MFCD00066635
UNSPSC-Code:
41106305
eCl@ss:
32160414
PubChem Substanz-ID:
329747370
NACRES:
NA.51

Qualitätsniveau

100

Assay

≥90%

Form

powder or crystals

Optische Aktivität

[α]20/D −29.6±1°, c = 0.5% in 0.5 M Na2HPO4

Verunreinigungen

≤10% water

Lagertemp.

−20°C

SMILES String

[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H15N5O10P2.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChIKey

ORKSTPSQHZNDSC-IDIVVRGQSA-L

Verwandte Kategorien

Anwendung

Adenosine 5′-diphosphate disodium salt has been used as a purinergic G protein-coupled receptor P2Y12 agonistin platelet activation tests in blood samples.

Biochem./physiol. Wirkung

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by ATP synthases. ADP affects platelet activation through its interaction with purinergic receptors P2Y1 and P2Y12. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Millipore

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USP

USP

1012178

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Sigma-Aldrich

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PloS one, 12(2), e0172265-e0172265 (2017-02-17)
Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist
Sven Van Poucke et al.
PloS one, 13(6), e0193657-e0193657 (2018-06-22)
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable impact on hemostatic metabolism, both on platelet and on coagulation level. The potential hemostatic interference in
Béatrice Hechler et al.
Purinergic signalling, 7(3), 293-303 (2011-07-28)
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive
Lihui Long et al.
Experimental and therapeutic medicine, 19(5), 3177-3188 (2020-04-09)
The underlying mechanism of the myocardial protective effect of fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A rat model of cardiac ischemia/reperfusion
Sarah Jones et al.
British journal of haematology, 153(1), 83-91 (2011-02-22)
ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) paradoxically enhances ADP-evoked aggregation, an effect that has been attributed to
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