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Y0001532

Norethisteronacetat für die Systemeignung

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

19-Norethisteron-17-acetat, 17α-Acetylenyl-17β-hydroxy-19-nor-4-androsten-3-on-17-acetat, 17α-Acetylenyl-19-nortestosteron-17β-acetat, 17-Hydroxy-19-nor-17a-4-pregnen-20-yn-3-onacetat, 19-Norethindron-acetat

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About This Item

Empirische Formel (Hill-System):
C22H28O3
CAS-Nummer:
51-98-9
Molekulargewicht:
340.46
MDL-Nummer:
MFCD00271615
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329831477
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

norethisterone

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1

InChIKey

IMONTRJLAWHYGT-ZCPXKWAGSA-N

Angaben zum Gen

human ... PGR(5241)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Norethisterone acetate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazardEnvironment
GHS08,GHS09

Signalwort

Danger

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).
Africander D J, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 143, 404-415 (2014)
F Pommier et al.
Journal of chromatography. A, 750(1-2), 75-81 (1996-10-25)
An analytical method for the determination of norethisterone acetate (NETA) in human plasma by capillary gas chromatography-mass-selective detection (GC-MS), with testosterone acetate as internal standard, was developed and validated. After addition of the internal standard, the compounds were extracted from
Bente Juel Riis et al.
American journal of obstetrics and gynecology, 187(4), 1101-1116 (2002-10-22)
This article is focused on the use of norethisterone acetate as progestogen in hormone replacement therapy. Emphasis is made on the fact that the primary reason for adding a progestogen to hormone replacement therapy is to protect the endometrium against
Norethisterone and norethisterone acetate.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 21, 441-460 (1979-12-01)
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone
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