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Y0001365

Etoposid für die Systemeignung

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

Etoposid, 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethyliden-β-D-glucopyranosid), VP-16-213

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About This Item

Empirische Formel (Hill-System):
C29H32O13
CAS-Nummer:
33419-42-0
Molekulargewicht:
588.56
MDL-Nummer:
MFCD00869325
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329831385
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

etoposide

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26

InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChIKey

VJJPUSNTGOMMGY-MRVIYFEKSA-N

Angaben zum Gen

human ... TOP2A(7153) , TOP2B(7155)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Etoposide for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Etopsid ist ein Antitumormittel, das Komplexe mit Topoisomerase II und DNA bildet, um die Doppelstrang- und Einzelstrangspaltung von DNA zu verstärken und die erneute Ligation reversibel zu hemmen. Blockiert den Zellzyklus in der S-Phase und G2-Phase des Zellzyklus; leitet die Apoptose in normalen und Tumorzelllinien ein; hemmt die Synthese des Onkoproteins MDM2 und leitet die Apoptose in Tumorzelllinien, die MDM2 überexprimieren ein.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Ähnliches Produkt

Produkt-Nr.
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Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

WGK

WGK 3

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Analysenzertifikate (COA)

Lot/Batch Number

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Sachiko Ezoe
International journal of environmental research and public health, 9(7), 2444-2453 (2012-08-02)
Etoposide is an anticancer agent, which is successfully and extensively used in treatments for various types of cancers in children and adults. However, due to the increases in survival and overall cure rate of cancer patients, interest has arisen on
Olga V Leontieva et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8832-8837 (2014-06-04)
During cell cycle arrest caused by contact inhibition (CI), cells do not undergo senescence, thus resuming proliferation after replating. The mechanism of senescence avoidance during CI is unknown. Recently, it was demonstrated that the senescence program, namely conversion from cell
Y-L Kwong et al.
Leukemia, 28(4), 865-870 (2013-07-12)
Circulating Epstein-Barr virus (EBV) DNA is a biomarker of EBV-associated malignancies. Its significance in natural killer/T-cell lymphoma treated with the novel regimen SMILE was investigated. EBV DNA was quantified with a World Health Organization EBV standard in 910 plasma samples
Abukar Ali et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 107-116 (2014-10-11)
Permanent reduction in joint function is a severe postinfectious complication in patients with Staphylococcus aureus septic arthritis. We undertook this study to determine whether this reduction in joint function might be caused by persistent joint inflammation after the adequate eradication
Nouhoum Sako et al.
The American journal of pathology, 184(11), 2899-2907 (2014-09-10)
Extranodal natural killer-T-cell lymphoma (NKTCL) of nasal type is a malignant disorder of cytotoxic lymphocytes of natural killer or more rarely T cells, associated with clonal Epstein-Barr virus infection. NKTCL is an aggressive neoplasm with very poor prognosis. Although the
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