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Y0000282

Tioconazol für die Systemeignung

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

Tioconazol, 1-{2-[(2-Chlor-3-thienyl)-methoxy]-2-(2,4-dichlor-phenyl)-ethyl}-1H-imidazol, Thioconazol

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About This Item

Empirische Formel (Hill-System):
C16H13Cl3N2OS
CAS-Nummer:
65899-73-2
Molekulargewicht:
387.71
MDL-Nummer:
MFCD00057276
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329830898
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

tioconazole

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1

InChI

1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

InChIKey

QXHHHPZILQDDPS-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Tioconazole for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Tioconazol ist ein Antipilzmedikament, das wirksamer als Fluconazol oder Voriconazol gegenüber Candida glabrata -Mutantenstämmen ist. Sein Wirkungsmechanismus beruht auf Membranzerstörung und Verlust der intrazellulären ATP.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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S P Clissold et al.
Drugs, 31(1), 29-51 (1986-01-01)
Tioconazole is a substituted imidazole antimicrobial agent structurally related to other drugs in this group. It has been shown to have a broad spectrum of activity in vitro against dermatophytes and yeasts, as well as against some chlamydia, trichomonads and
Pénélope A Andreux et al.
Scientific reports, 4, 5285-5285 (2014-06-14)
Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has proven challenging. It requires the measurement of
S Manzoor et al.
Talanta, 134, 1-7 (2015-01-27)
This work encompasses a direct and coherent strategy to synthesise a molecularly imprinted polymer (MIP) capable of extracting fluconazole from its sample. The MIP was successfully prepared from methacrylic acid (functional monomer), ethyleneglycoldimethacrylate (crosslinker) and acetonitrile (porogenic solvent) in the

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