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PHR1658

Supelco

Dimenhydrinat

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Dimenhydrinat, N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlortheophyllinat

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About This Item

Empirische Formel (Hill-System):
C17H21NO · C7H7ClN4O2
CAS-Nummer:
523-87-5
Molekulargewicht:
469.96
EG-Nummer:
208-350-8
MDL-Nummer:
MFCD00054265
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823536
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to Ph. Eur. D2000000
traceable to USP 1206006

API-Familie

dimenhydrinate

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

CN1C(=O)N(C)c2nc(Cl)[nH]c2C1=O.CN(C)CCOC(c3ccccc3)c4ccccc4

InChI

1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)

InChIKey

NFLLKCVHYJRNRH-UHFFFAOYSA-N

Angaben zum Gen

human ... HRH1(3269)

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Verwandte Kategorien

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dimenhydrinate, a diphenhydramine salt of 8-chlorotheophylline, exhibits antihistaminic activity, with antimuscarinic and sedative effects. It finds its major application as an antiemetic drug in the prevention and treatment of motion sickness.

Anwendung

Dimenhydrinate may be used as a pharmaceutical reference standard for the determination of the analyte in traditional Chinese medicine and pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC3017 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAD0802
LRAC3221
LRAC3017
LRAA5759

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Sigma-Aldrich

Sigma-Aldrich

SRE0027

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Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography: Stress test for stability evaluation.
Barbas C, et al.
Journal of Chromatography A, 870(1-2), 97-103 (2000)
Simultaneous determination of Dimenhydrinate, Cinnarizine and Cinnarizine impurity by TLC and HPLC chromatographic methods.
Ahmed AB, et al.
Bulletin of Faculty of Pharmacy, Cairo University , 55(1), 163-169 (2017)
HPLC and GC?MS screening of Chinese proprietary medicine for undeclared therapeutic substances.
Liu SY, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(5-6), 983-992 (2001)

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