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PHR1530

Supelco

Acetanilid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

N-Phenylacetamid, Essigsäure-anilid

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About This Item

Lineare Formel:
CH3CONHC6H5
CAS-Nummer:
Molekulargewicht:
135.16
Beilstein:
606468
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1003042

Dampfdichte

4.65 (vs air)

Dampfdruck

1 mmHg ( 114 °C)

Beschreibung

API family: acetaminophen

API-Familie

acetaminophen, paracetamol

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

1004 °F

Verpackung

pkg of 200 mg

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

bp

304 °C (lit.)

mp (Schmelzpunkt)

113-115 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

CC(=O)Nc1ccccc1

InChI

1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)

InChIKey

FZERHIULMFGESH-UHFFFAOYSA-N

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Allgemeine Beschreibung

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.

Anwendung

This pharmaceutical secondary standard can also be used as follows:

  • Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methods
  • Simultaneous determination of paracetamol and phenylephrine hydrochloride in the presence of paracetamol-related impurities using capillary zone electrophoresis (CZE) in their combined tablet forms

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA3648 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

WGK

WGK 1

Flammpunkt (°F)

321.8 °F

Flammpunkt (°C)

161 °C


Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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PHR1973

Acetaminophen-Unreinheit I

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4-Acetamidophenol Pharmaceutical Secondary Standard; Certified Reference Material

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Acetaminophen-Unreinheit E Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1971

Acetaminophen-Unreinheit E

Acetanilid purified by sublimation, ≥99.9%

Sigma-Aldrich

397229

Acetanilid

Acetanilid puriss. p.a., ≥99.5% (CHN)

Sigma-Aldrich

00401

Acetanilid

Acetaminophen-verwandte Verbindung C United States Pharmacopeia (USP) Reference Standard

USP

1003031

Acetaminophen-verwandte Verbindung C

Supelco

Supelco

CRM40481

Longifolene solution

Capillary zone electrophoresis as a quality assessment tool of paracetamol and phenylephrine hydrochloride in presence of paracetamol impurities
FARID J, et al.
Turkish Journal of Chemistry, 46, 217-223 (2022)
Fabrice Gritti et al.
Journal of chromatography. A, 1355, 179-192 (2014-07-09)
The mass transfer mechanism in four prototype columns (2.1 and 3.0×50mm, 2.1 and 3.0×100mm) packed with 1.9μm fully porous Titan-C18 particles was investigated by using two previously reported home-made protocols. The first one was used to measure the eddy dispersion
Naoki Aizawa et al.
Neurourology and urodynamics, 34(4), 368-374 (2014-02-18)
We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adrenoceptor agonist, and oxybutynin, an antimuscarinic agent, can affect the SAAs in such condition. Twenty-nine female Sprague-Dawley
Hassan A Alhazmi et al.
Journal of pharmaceutical and biomedical analysis, 107, 311-317 (2015-02-02)
In this work, the behavior of several metal ions with different globular proteins was investigated by affinity capillary electrophoresis. Screening was conducted by applying a proper rinsing protocol developed by our group. The use of 0.1M EDTA in the rinsing
Yan Ma et al.
Journal of chromatography. A, 1383, 47-57 (2015-02-05)
Prototype small-size (1.0mm I.D., 5cm long) columns for reversed-phase HPLC were evaluated in relation to instrument requirements. The performance of three types of columns, monolithic silica and particulate silica (2μm, totally porous and 2.6μm, core-shell particles) was studied in the

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