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PHR1243

Supelco

Guanin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

2-Amino-1,7-dihydro-6H-purin-6-on, 2-Amino-6-hydroxy-purin, 2-Aminohypoxanthin

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About This Item

Empirische Formel (Hill-System):
C5H5N5O
CAS-Nummer:
73-40-5
Molekulargewicht:
151.13
Beilstein:
9680
EG-Nummer:
200-799-8
MDL-Nummer:
MFCD00071533
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823247
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 879
traceable to USP 1302156

API-Familie

ganciclovir, valacyclovir, aciclovir

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

>300 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

NC1=Nc2[nH]cnc2C(=O)N1

InChI

1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChIKey

UYTPUPDQBNUYGX-UHFFFAOYSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Guanine is one of the building blocks of both RNA and DNA that plays a significant role in protein biosynthesis as well as the storage of genetic information.

Anwendung

Guanine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0250 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Ganciclovir Unreinheit (gemischt), European Pharmacopoeia (EP) Reference Standard

Y0001129

Ganciclovir, European Pharmacopoeia (EP) Reference Standard

1302156

Guanin, United States Pharmacopeia (USP) Reference Standard

1288306

Ganciclovir, United States Pharmacopeia (USP) Reference Standard

1288317

Ganciclovir-verwandte Verbindung A, United States Pharmacopeia (USP) Reference Standard

1288339

Ganciclovir-mono-N-methylvalinat, United States Pharmacopeia (USP) Reference Standard

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Ganciclovir, Pharmaceutical Secondary Standard; Certified Reference Material

BP879

Guanin, British Pharmacopoeia (BP) Reference Standard

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAC0250
LRAA9047
P500243

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

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Sigma-Aldrich

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Sigma-Aldrich

P55805

Purin

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Sigma-Aldrich

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Rapid and simple determination of adenine and guanine in DNA extract by micellar electrokinetic chromatography with indirect laser-induced fluorescence detection
Wang W, et al.
Talanta, 74(4), 1050-1055 (2008)
Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets
Monajjemzadeh F, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 73(3), 404-413 (2009)
Jean Cadet et al.
Accounts of chemical research, 41(8), 1075-1083 (2008-08-01)
Nuclear DNA and other molecules in living systems are continuously exposed to endogenously generated oxygen species. Such species range from the unreactive superoxide radical (O2*-)the precursor of hydrogen peroxide (H2O2)to the highly reactive hydroxyl radical (*OH). Exogenous chemical and physical
S Kawanishi et al.
Mutation research, 488(1), 65-76 (2001-02-27)
Reactive species generated by chemicals and UV radiation can cause sequence-specific DNA damage and play important roles in mutagenesis, carcinogenesis and aging. We have investigated sequence specificity of oxidative stress-mediated DNA damage by using 32P-labeled DNA fragments obtained from the
Barbara van Loon et al.
DNA repair, 9(6), 604-616 (2010-04-20)
The maintenance of genetic stability is of crucial importance for any form of life. Prior to cell division in each mammalian cell, the process of DNA replication must faithfully duplicate the three billion bases with an absolute minimum of mistakes.
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