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Merck

LIGHTOX21

Sigma-Aldrich

LightOx21

≥95% (HPLC)

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About This Item

Empirische Formel (Hill-System):
C21H21NO2
CAS-Nummer:
Molekulargewicht:
319.40
UNSPSC-Code:
12352200

Assay

≥95% (HPLC)

Form

powder

Lagertemp.

2-8°C

Anwendung

Fluorescence microscopy, fluorescent retinoid binding assay, fluorescence spectroscopy.

Biochem./physiol. Wirkung

Strong ligand for retinoic acid receptor proteins

Leistungsmerkmale und Vorteile

LightOx21 is a synthetic analogue of all-trans-retinoic acid (ATRA), that exhibits solvatochromatic fluorescence emission when excited with UV or 405 nm light. The compound is a strong ligand for the retinoic acid receptor proteins (RARs) and related cellular retinoic acid binding proteins (CRABPI/II) and can, therefore, be used as a replacement for ATRA in cellular assays involving retinoid signaling processes. LightOx21 can be utilised to study retinoid behaviour using fluorescence microscopy, employed in a competitive fluorometric ligand-binding assay for direct determination of the strength of binding of non-fluorescent retinoids to a protein target, and as a fluorophore in fluorescence spectroscopy.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Sonstige Hinweise

Chemical Equivalency 1ea=1mg

Rechtliche Hinweise

LightOx is a trademark of LightOx Ltd.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Artikel

Fluorescent retinoic acid analogues for use in cellular imaging, protein-ligand binding assays, and flow cytometry to bypass traditional problems associated with fluorescent probes.

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