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D2920000

Disopyramid

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

α-Diisopropylaminoethyl-α-phenylpyridin-2-acetamid

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About This Item

Empirische Formel (Hill-System):
C21H29N3O
CAS-Nummer:
3737-09-5
Molekulargewicht:
339.47
MDL-Nummer:
MFCD00057366
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329798759
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

disopyramide

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C

InChI

1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

InChIKey

UVTNFZQICZKOEM-UHFFFAOYSA-N

Angaben zum Gen

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Disopyramide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Class IA antiarrhythmic; sodium channel blocker

Verpackung

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.

Sonstige Hinweise

Sales restrictions may apply.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Exclamation markHealth hazard
GHS07,GHS08

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

R N Brogden et al.
Drugs, 34(2), 151-187 (1987-08-01)
Disopyramide is a widely used class IA antiarrhythmic drug with a pharmacological profile of action similar to that of quinidine and procainamide. Over the past 10 years disopyramide has demonstrated its efficacy in ventricular and atrial arrhythmias. In therapeutic trials
[Hypoglycemia induced or facilitated by disopyramide].
C Seriès
La Revue de medecine interne, 9(5), 528-529 (1988-11-01)
B Brembilla-Perrot et al.
Archives des maladies du coeur et des vaisseaux, 84(6), 837-842 (1991-06-01)
The aim of this study was to assess the effect of delayed release Disopyramide 500 mg daily on sinus node function in 12 subjects with sinus node dysfunction and supraventricular and/or ventricular excitability. An ECG, Holter monitoring and electrophysiological studies
E V Granowitz et al.
Pacing and clinical electrophysiology : PACE, 23(9), 1433-1435 (2000-10-12)
A patient on disopyramide developed disopyramide toxicity when treated concurrently with azithromycin. Evidence of toxicity included an elevated serum disopyramide level and ventricular tachycardia requiring cardioversion. The azalide antibiotic presumably inhibited dealkylation of disopyramide to its major metabolite, mono-N-dealkyldisopyramide. Physicians
[Disopyramide, mexiletine, aprindine].
M Suzuki
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 989-993 (1995-02-01)
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