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Merck

91928

Supelco

2′,4′,6′-Trihydroxyacetophenon Monohydrat

matrix substance for MALDI-MS, ≥99.5%

Synonym(e):

2-Acetyl-phloroglucin, THAP

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About This Item

Lineare Formel:
(HO)3C6H2COCH3·H2O
CAS-Nummer:
Molekulargewicht:
186.16
Beilstein:
9288656
MDL-Nummer:
UNSPSC-Code:
12000000
PubChem Substanz-ID:
NACRES:
NA.21

Qualität

matrix substance for MALDI-MS

Qualitätsniveau

Assay

≥99.5% (HPLC)
≥99.5%

Form

solid

chemische Klasse(n) des Analyten

glycans, oligonucleotides, peptides, proteins

Methode(n)

MALDI-MS: suitable

Farbe

light yellow

mp (Schmelzpunkt)

218-222 °C
219-221 °C (lit.)

Kationenspuren

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Eignung

in accordance for UV test

SMILES String

O.CC(=O)c1c(O)cc(O)cc1O

InChI

1S/C8H8O4.H2O/c1-4(9)8-6(11)2-5(10)3-7(8)12;/h2-3,10-12H,1H3;1H2

InChIKey

GDSIBPPJKSBCMF-UHFFFAOYSA-N

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Allgemeine Beschreibung

MALDI-MS analyzes require highest purity matrices and reagents, as organic or trace metal contamination causes adverse effects during crystallization, ionization or measurement. Therefore, our portfolio of MALDI matrices and reagents such as 2′,4′,6′-Trihydroxyacetophenone monohydrate are designed to fulfill the demanding requirements of today′s challenging applications.

Anwendung

Verwendet in der MALDI-Analyse von sauren Glycanen und Glycopeptiden im Negativ-Ionen-Modus. Niedrigere Nachweisgrenze als 6-Aza-2-thiothimidin.
2′,4′,6′-Trihydroxyacetophenone monohydrate has been used as a matrix for oligosaccharide and glycopeptide analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF).

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Preisangaben

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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J Wang et al.
Journal of agricultural and food chemistry, 47(5), 2009-2015 (1999-12-20)
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful new technique that will have a great impact on food analysis. This study is the first to demonstrate the applicability of MALDI-MS to perform both qualitative and quantitative analyses of anthocyanins
U Pieles et al.
Nucleic acids research, 21(14), 3191-3196 (1993-07-11)
We report the analysis and characterization of natural and modified oligonucleotides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The present technology was highly improved for this class of compounds by using a new matrix, 2,4,6-trihydroxy acetophenone, together
Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Papac, Damon I., Anissa Wong, and Andrew JS Jones.
Analytical Chemistry, 68.18, 3215-3223 (1996)
D I Papac et al.
Analytical chemistry, 68(18), 3215-3223 (1996-09-15)
2,5-Dihydroxybenzoic acid (DHB) is the most commonly used matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF) of oligosaccharides. Because acidic, sialylated oligosaccharides are detected at only the low picomole level with DHB, alternative matrices were screened to identify a
Gerard Artigas et al.
The Journal of organic chemistry, 80(4), 2155-2164 (2015-01-21)
We describe the synthesis and characterization of ametantrone-containing RNA ligands based on the derivatization of this intercalator with two neamine moieties (Amt-Nea,Nea) or with one azaquinolone heterocycle and one neamine (Amt-Nea,Azq) as well as its combination with guanidinoneamine (Amt-NeaG4). Biophysical

Artikel

Mass Spectrometry of Glycans, method comparison and products

Protokolle

Mass Spectrometry of Glycans

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