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91503

Supelco

Palmitoyl-L-carnitin

analytical standard

Synonym(e):

(2R)-3-Carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)-oxy]-1-propanaminium Inneres Salz, L-Carnitin-hexadecanoylester, C16-Carnitin, Hexadecanoyl-L-carnitin

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About This Item

Empirische Formel (Hill-System):
C23H45NO4
CAS-Nummer:
2364-67-2
Molekulargewicht:
399.61
Beilstein:
4152034
UNSPSC-Code:
41116107
NACRES:
NB.21

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥95.0% (HPLC)

Optische Aktivität

[α]/D -17.0±2.0°, c = 1 in methanol

Haltbarkeit

limited shelf life, expiry date on the label

Verunreinigungen

≤10% water

Anwendung(en)

clinical testing

Format

neat

Lagertemp.

2-8°C

SMILES String

C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC([O-])=O

InChI

1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1

InChIKey

XOMRRQXKHMYMOC-OAQYLSRUSA-N

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Allgemeine Beschreibung

Palmitoyl-L-carnitine (PLC) belongs to the class of long chain acylcarnitine compounds. It is an acyl-chain ester, which can be obtained from L-carnitine via acylcarnitine family transferase. PLC is reported to be used for the phospholipid reacylation in erythrocyte membrane ghosts.

Anwendung

Palmitoyl-L-carnitine may be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS). The feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients is investigated. It may also be used as an analytical reference standard for the separation and identification of underivatized palmitoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).

Empfohlene Produkte

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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08984

Butyryl-L-carnitin

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Supelco

92107

O-Acetyl-L-Carnitin -hydrochlorid

Octanoyl-L-carnitin ≥97.0% (TLC)

Sigma-Aldrich

50892

Octanoyl-L-carnitin

L-Carnitin -hydrochlorid analytical standard

Supelco

94954

L-Carnitin -hydrochlorid

L-Carnitin Inneres Salz synthetic, ≥98%

Sigma-Aldrich

C0158

L-Carnitin Inneres Salz

L-Carnitin -hydrochlorid synthetic, ≥98%

Sigma-Aldrich

C0283

L-Carnitin -hydrochlorid

Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes
Arduini A, et al.
The Journal of Biological Chemistry, 267(18), 12673-12681 (1992)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled

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