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3-Hydroxyisovaleryl-L-carnitin

analytical standard

Synonym(e):

(2R)-3-Carboxy-2-(3-hydroxy-3-methyl-1-oxobutoxy)-N,N,N-trimethyl-1-propanaminium Inneres Salz

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About This Item

Empirische Formel (Hill-System):
C12H23NO5
CAS-Nummer:
99159-87-2
Molekulargewicht:
261.31
Beilstein:
10549761
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥90.0% (HPLC)

Optische Aktivität

[α]/D -17.0±2.0°, c = 0.1 in H2O

Haltbarkeit

limited shelf life, expiry date on the label

Verunreinigungen

≤15% water (calc. on elemental analysis)

Anwendung(en)

clinical testing

Format

neat

Lagertemp.

2-8°C

SMILES String

C[N+](C)(C)C[C@H](OC(CC(C)(O)C)=O)CC([O-])=O

InChI

1S/C12H23NO5/c1-9(2)6-11(16)18-12(17,7-10(14)15)8-13(3,4)5/h9,17H,6-8H2,1-5H3

InChIKey

DHRNMNHPSWBJEN-UHFFFAOYSA-N

Verwandte Kategorien

Biochem./physiol. Wirkung

3-Hydroxyisovaleryl-L-carnitine is an endogenous metabolite that can result from impairment in the leucine catabolic pathway. 3-Hydroxyisovaleryl-L-carnitine was observed in plasma and urine of patient with isolated 3-methylcrotonyl-CoA carboxylase deficiency and is used as biomarker of biotin deficiency in humans and other metabolic disorders.

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WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
BCCD4258
BCCD1947
BCBX5390
BCBS1120
BCBX5389

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[(3R)-3-Hydroxytetradecanoyl]-L-carnitin analytical standard

Supelco

52002

[(3R)-3-Hydroxytetradecanoyl]-L-carnitin

trans-2-Tetradecenoyl-L-carnitin analytical standard

Supelco

40733

trans-2-Tetradecenoyl-L-carnitin

Butyryl-L-carnitin analytical standard

Supelco

08984

Butyryl-L-carnitin

Isobutyryl-L-carnitin ≥97.0% (HPLC)

Sigma-Aldrich

51085

Isobutyryl-L-carnitin

Oleoyl-L-carnitin -hydrochlorid 99% (CP)

Sigma-Aldrich

597562

Oleoyl-L-carnitin -hydrochlorid

Urinary Excretion of 3-Hydroxyisovaleryl Carnitine Is an Early and Sensitive Indicator of Marginal Biotin Deficiency in Humans.
Stratton, S.L., et al.
The Journal of Nutrition, 141, 353-358 (2011)
Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans.
Stratton, S.L., et al.
American Journal of Clinical Nutrition, 92, 1399-1405 (2010)
Quantitative Measurement of Urinary Excretion of 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as an Indicator of Biotin Status in Humans.
Horvath, T.D., et al.
Analytical Chemistry, 82, 9543-9548 (2010)
3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency.
van Hove, J.L.K., et al.
Journal of inherited metabolic disease, 18, 592-601 (1995)

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