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Supelco

Idebenon

analytical standard

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About This Item

Empirische Formel (Hill-System):
C19H30O5
CAS-Nummer:
58186-27-9
Molekulargewicht:
338.44
MDL-Nummer:
MFCD00274552
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329760681
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥97.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O

InChI

1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3

InChIKey

JGPMMRGNQUBGND-UHFFFAOYSA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
BCCD5091
BCCC1147
BCCB8933
BCCB6828
BCCB5472

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Vanna Geromel et al.
Molecular genetics and metabolism, 77(1-2), 21-30 (2002-10-03)
While there have been major advances in both the identification of the molecular basis and our understanding of mitochondrial pathology, the clinical management of patients with mitochondrial respiratory chain disease is still essentially supportive. Quinones are the only pharmacological agents
H Morimoto
Die Naturwissenschaften, 76(5), 200-205 (1989-05-01)
Syntheses of some metabolites of ubiquinone and of related compounds are described. Idebenone (QSA-10), a methyl-dimethoxy-benzoquinone bearing an omega-hydroxydecyl side chain in 3-position, restored the oxidation of succinate and of NADH in ubiquinone-depleted mitochondrial preparations and showed a stabilizing effect
Thomas Meier et al.
Journal of neurology, 256 Suppl 1, 25-30 (2009-04-11)
This paper reviews the history and pre-clinical development of idebenone and summarises the results of clinical studies, published from 1999 to 2008, on the use of idebenone in the treatment of patients with Friedreich ataxia (FRDA). As a benzoquinone that
Patricia Farris
Dermatologic therapy, 20(5), 322-329 (2007-11-30)
The use of topical antioxidants is gaining favor among dermatologists because of their broad biologic activity. Many are not only antioxidants but also have antiinflammatory and anticarcinogenic activities. Thus for dermatologists these cosmeceuticals have many potential applications. In general, topical
Caterina Tonon et al.
Expert opinion on pharmacotherapy, 9(13), 2327-2337 (2008-08-20)
Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant that was first administrated to Friedreich's
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