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MPTMAG-49K

Millipore

MILLIPLEX® Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay

The analytes available for this multiplex kit are: ACTH, BDNF, FSH, GH, Prolactin, TSH, LH.

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About This Item

UNSPSC-Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Qualitätsniveau

200

Speziesreaktivität

mouse

Hersteller/Markenname

Milliplex®

assay range

accuracy: 96-101%
standard curve range: 12.2-50,000 pg/mL
(TSH)
standard curve range: 122-500,000 pg/mL
(Prolactin)
standard curve range: 2.4-10,000 pg/mL
(ACTH)
standard curve range: 2.4-10,000 pg/mL
(BDNF)
standard curve range: 24.4-100,000 pg/mL
(FSH)
standard curve range: 4.9-20,000 pg/mL
(GH)
standard curve range: 4.9-20,000 pg/mL
(LH)
inter-assay cv: <20%
intra-assay cv: <15%

Methode(n)

multiplexing: suitable

Nachweisverfahren

fluorometric (Luminex xMAP)

Versandbedingung

wet ice

Verwandte Kategorien

Allgemeine Beschreibung

Called the “master gland” because it controls many other endocrine glands, the pituitary secretes several key hormones that play important roles in the regulation of metabolism, growth, and reproduction. Piuitary hormones are responsible for the stimulation of the adrenal gland (ACTH), thyroid gland (TSH), ovaries and testes (FSH, LH) and breast milk production (prolactin), as well as blood pressure and the amount of water excreted by the kidneys. Through its connection with the pituitary, the hypothalamus modulates endocrine function by detecting hormone levels. Brain-Derived Neurotrophic Factor (BDNF) is a member of NGF family of neurotrophic factors which are required for differentiation and survival of specific neuronal sub-populations.

MILLIPLEX® Mouse Pituitary Panel is a 7-plex kit to be used for the simultaneous quantification of any or all of the following analytes in mouse serum, plasma, and tissue culture samples: ACTH, BDNF, FSH, GH, Prolactin, TSH and LH. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Endocrine

Anwendung

  • Analytes: ACTH, BDNF, FSH, GH, LH, Prolactin, TSH
  • Recommended Sample Type: Mouse serum, plasma, cell/tissue culture supernatants or lysates
  • Recommended Sample Dilution: 10 μL per well of undiluted serum or plasma; cell/tissue culture samples may require dilution in an appropriate control medium.
  • Assay Run Time: For greater sensitivity an overnight incubation is recommended, (16-18 hours) at 2-8°C. Alternatively, incubate for 2 hours at room temperature (20-25°C).
  • Research Category: Endocrine
  • Research Subcategory: Metabolism

Leistungsmerkmale und Vorteile

Design your multiplex kit by choosing available analytes within this panel.

Sonstige Hinweise

Sensitivity: Please see kit protocol for sensitive’s of individual biomarkers.

Rechtliche Hinweise

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Piktogramme

Skull and crossbonesEnvironment
GHS06,GHS09

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

WGK

WGK 3

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

D H Loh et al.
Journal of biological rhythms, 29(5), 355-369 (2014-09-26)
The female reproductive cycle is gated by the circadian timing system and may be vulnerable to disruptions in the circadian system. Prior work suggests that vasoactive intestinal peptide (VIP)-expressing neurons in the suprachiasmatic nucleus (SCN) are one pathway by which
Typhanie Dumontet et al.
JCI insight, 3(2) (2018-01-26)
The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher primates increase prepubertal androgen secretion, is unknown. Using cell-fate mapping and gene deletion studies in
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Pitetti, JL; Calvel, P; Zimmermann, C; Conne, B; Papaioannou, MD; Aubry, F; Cederroth et al.
Molecular Endocrinology null
Tomohiro Terasaka et al.
Endocrinology, 160(8), 1999-2014 (2019-06-13)
Gonadotropin secretion, which is elicited by GnRH stimulation of the anterior pituitary gonadotropes, is a critical feature of reproductive control and the maintenance of fertility. In addition, activation of the GnRH receptor (GnRHR) regulates transcription and translation of multiple factors
Thomas Blum et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(30), 15236-15243 (2019-07-10)
Dopamine neurons of the hypothalamic arcuate nucleus (ARC) tonically inhibit the release of the protein hormone prolactin from lactotropic cells in the anterior pituitary gland and thus play a central role in prolactin homeostasis of the body. Prolactin, in turn
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