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FCMAB104A4

Sigma-Aldrich

Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor™ 488

clone 3H10, from mouse, ALEXA FLUOR™ 488

Synonym(e):

H3 histone, family 3A, H3S10P, Histone H3 (phospho S10), H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B)

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

ALEXA FLUOR™ 488

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

3H10, monoclonal

Speziesreaktivität

human

Methode(n)

flow cytometry: suitable

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

NM_003493

UniProt-Hinterlegungsnummer

Q16695

Versandbedingung

wet ice

Posttranslationale Modifikation Target

phosphorylation (pSer10)

Angaben zum Gen

human ... HIST1H3F(8968)

Verwandte Kategorien

Allgemeine Beschreibung

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Spezifität

Broad species cross-reactivity is expected.
Histone H3 phosphorylated at Ser10

Immunogen

A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.
Epitope: Ser10

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Apoptose & Krebs
Research Sub Category
Histone

Zellzyklus, DNA-Replikation & -Reparatur
Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor™ 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Alexa Fluor 488 and validated for use in FC.

Qualität

Evaluated by Flow Cytometry with Jurkat cells.

Zielbeschreibung

17 kDa observed

Physikalische Form

Protein G Purified
Purified mouse IgG1k conjugated to Alexa Fluor™ 488 in PBS with 15mg/mL BSA and less than 0.09% sodium azide.

Lagerung und Haltbarkeit

Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Hinweis zur Analyse

Control
Jurkat Cells

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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