Beclin-1 Activator II, retro-inverso TAT-Beclin-1

Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.

Cell permeable: yes

Primary Target
GAPR-1/GLIPR2

Reversible: yes

Packaged under inert gas

Toxicity: Standard Handling (A)

(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH

Supplied as a trifluoroacetate salt.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Shoji-Kawata, S., et al. 2013. Nature.494, 201.

Sold under license of US Patent 8,722,628.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany