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07-817

Sigma-Aldrich

Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody

Upstate®, from rabbit

Synonym(e):

Glycogen synthase 1, GYS1, GS

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

human, mouse

Hersteller/Markenname

Upstate®

Methode(n)

western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_002103.3

UniProt-Hinterlegungsnummer

P13807

Versandbedingung

dry ice

Posttranslationale Modifikation Target

phosphorylation (pSer641/pSer645)

Angaben zum Gen

human ... GYS1(2997)

Spezifität

Glycogen Synthase phosphorylated on serine residues 641 and 645
Predicted to cross-react with rat based on sequence homology (100%), but have not been tested.

Immunogen

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Glycogen Synthase (Ser641/Ser645).

Anwendung

Research Sub Category
Insulin-/stoffwechselassoziierte Signalübertragung

PI3K-, Akt-, & mTOR-Signalübertragung
Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody is an antibody against phospho-Glycogen Synthase(Ser641/Ser645) for use in WB.

Qualität

Routinely evaluated by immunoblot.

Zielbeschreibung

85 kDa

Physikalische Form

Affinity purified rabbit polyclonal IgG in Dulbecco’s PBS, pH 7.3 with 1.0 mg/mL BSA, 0.05% sodium azide, and 50% glycerol.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Laura Marr et al.
Nature communications, 13(1), 3372-3372 (2022-06-12)
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with glycogen synthase (GS), where GS is activated by glucose-6-phosphate (G6P) and inactivated by phosphorylation. We
C T Shearn et al.
Biochemistry, 50(19), 3984-3996 (2011-03-29)
The production of reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE) is a key component of the pathogenesis in a spectrum of hepatic diseases involving oxidative stress such as alcoholic liver disease (ALD). One consequence of ALD is increased insulin resistance in
Cole D Davidson et al.
Journal of the Endocrine Society, 5(8), bvab102-bvab102 (2021-07-15)
Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. Anaplastic thyroid cancer (ATC) is highly aggressive, dedifferentiated, and patients have a median survival of fewer than 6 months. Oncogenic
Paras S Minhas et al.
Nature, 590(7844), 122-128 (2021-01-22)
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6.

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