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850185P

Avanti

08:0 PI(4,5)P2

Avanti Polar Lipids

Synonym(e):

PIP2[4′,5′](8:0/8:0); 110665

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About This Item

Empirische Formel (Hill-System):
C25H58N3O19P3
CAS-Nummer:
852043-37-9
Molekulargewicht:
797.66
UNSPSC-Code:
51191904
NACRES:
NA.25

Beschreibung

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))

Hersteller/Markenname

Avanti Polar Lipids

Lipid-Typ

cardiolipins
phospholipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]

Verwandte Kategorien

Allgemeine Beschreibung

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

Anwendung

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transient receptor potential vanilloid 4 (TRPV4 N) terminus. It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β2AR).

Verpackung

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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18:1 PI(3,4)P2 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt), powder

Avanti

850153P

18:1 PI(3,4)P2

L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl

Sigma-Aldrich

P3584

L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl

1,2-Dipalmitoylphosphatidylinositol 4,5-diphosphate triammonium salt ≥98%, solid

Sigma-Aldrich

P7115

1,2-Dipalmitoylphosphatidylinositol 4,5-diphosphate triammonium salt

Hirn PI(4,5)P2 Avanti Polar Lipids

Avanti

840046X

Hirn PI(4,5)P2

18:1 PI(3,4,5)P3 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder

Avanti

850156P

18:1 PI(3,4,5)P3

16:0–18:1 PE Avanti Polar Lipids

Avanti

850757P

16:0–18:1 PE

Adenosin-5′-diphosphat Monokaliumsalz Dihydrat bacterial, ≥95%, powder

Sigma-Aldrich

A5285

Adenosin-5′-diphosphat Monokaliumsalz Dihydrat

18:1 PS (DOPS) Avanti Polar Lipids

Avanti

840035P

18:1 PS (DOPS)

Scott B Hansen et al.
Nature, 477(7365), 495-498 (2011-08-30)
The regulation of ion channel activity by specific lipid molecules is widely recognized as an integral component of electrical signalling in cells. In particular, phosphatidylinositol 4,5-bisphosphate (PIP(2)), a minor yet dynamic phospholipid component of cell membranes, is known to regulate
Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2
Goretzki B, et al.
Structure, 26(12), 1583-1593 (2018)
George Khelashvili et al.
Biochemistry, 51(39), 7685-7698 (2012-09-07)
Syntaxin (STX) is a N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein that binds to the plasma membrane and regulates ion channels and neurotransmitter transporters. Experiments have established the involvement of the N-terminal segment of STX in direct protein-protein interactions and
Tao Liang et al.
The Journal of biological chemistry, 289(9), 6028-6040 (2014-01-17)
In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (KATP channels). PIP2 binds the Kir6.2 subunit to open KATP channels. PIP2 also modifies Syn-1A clustering in plasma membrane (PM) that may alter Syn-1A actions on PM proteins
Structural and functional analysis of a beta2-adrenergic receptor complex with GRK5
Komolov KE, et al.
Cell, 169(3), 407-421 (2017)
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