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700077P

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FF-MAS

Avanti Polar Lipids

Synonym(e):

14-demethyl-14-dehydrolanosterol, 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol; follicular fluid meiosis-activating sterol

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About This Item

Empirische Formel (Hill-System):
C29H46O
CAS-Nummer:
64284-64-6
Molekulargewicht:
410.67
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (700077P-1mg)

Hersteller/Markenname

Avanti Polar Lipids

Versandbedingung

dry ice

Lagertemp.

−70°C

InChI

1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1

InChIKey

LFQXEZVYNCBVDO-PBJLWWPKSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Follicular fluid meiosis-activating sterol (FF-MAS) is an intermediate in the cholesterol biosynthetic pathway present in all cells, and may represent the physiological signal that instructs the oocyte to reinitiate meiosis.

Anwendung

FF-MAS has been used:
  • as a standard in gas chromatography/ mass spectroscopy (GC/MS) for profiling sterols of oligodendrocyte progenitor cells (OPCs)
  • as Dulbecco′s modified eagle medium (DMEM) medium supplement to test its effect on cancer cell viability
  • to evaluate its effect on LXRβ-overexpressing squamous carcinoma SCC61 cells

Biochem./physiol. Wirkung

14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. However, FF-MAS has low solubility and is metabolized to cholesterol rapidly.

Verpackung

5 mL Amber Glass Screw Cap Vial (700077P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Robert J Fakheri et al.
Steroids, 76(3), 211-215 (2010-10-19)
Autoregulation of cholesterol synthesis focuses on the 19 metabolic steps from lanosterol to cholesterol. Although synchronization of their rates of synthesis in all tissues was the paradigm, a known exception occurs in the ovary where a local increase in a
Autoregulation of cholesterol synthesis: Physiologic and pathophysiologic consequences
Fakheri RJ and Javitt NB
Steroids, 76(3), 211-215 (2011)
Two syntheses of FF-MAS
Blume T, et al.
Organic Letters, 5(11), 1837-1839 (2003)
Endogenous sterol metabolites regulate growth of EGFR/KRAS-dependent tumors via LXR
Gabitova L, et al.
Cell Reports, 12(11), 1927-1938 (2015)
A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro
MarinB, et al.
Human Reproduction, 19(10), 2340-2344 (2004)
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