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911690

Sigma-Aldrich

C5 Lenalidomide

≥95%

Synonym(e):

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC® research

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About This Item

Empirische Formel (Hill-System):
C13H13N3O3
CAS-Nummer:
191732-70-4
Molekulargewicht:
259.26
MDL-Nummer:
MFCD31692701
UNSPSC-Code:
12352101
NACRES:
NA.22

ligand

C5 Lenalidomide

Qualitätsniveau

100

Assay

≥95%

Form

powder

Eignung der Reaktion

reagent type: ligand

Lagertemp.

2-8°C

SMILES String

NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1

Verwandte Kategorien

Anwendung

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Sonstige Hinweise

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H361d,H373

Gefahreneinstufungen

Repr. 2 - STOT RE 2

Zielorgane

Blood

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Artikel

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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