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Merck

764698

Sigma-Aldrich

Poly(L-Lactid)

average Mn 20,000, PDI ≤1.1

Synonym(e):

L-lactid, polymer

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About This Item

Lineare Formel:
H(C3H4O2)nOCH3
UNSPSC-Code:
12162002
NACRES:
NA.23

Form

solid

Qualitätsniveau

Optische Aktivität

[α]22/D -153°, c = 0.5% in chloroform

Mol-Gew.

average Mn 20,000

Zeitrahmen für den Abbau

>3 years

Übergangstemp.

Tm 167-172 °C

PDI

≤1.1

Lagertemp.

2-8°C

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Allgemeine Beschreibung

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Anwendung

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

Leistungsmerkmale und Vorteile

High initial strength, good strength retention and high amount of crystallinity as much as 70% which in turn is responsible for the very slow degradation rate.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Poly-(L-lactid) viscosity ~4.0 dL/g, 0.1 % (w/v) in chloroform(25 °C)

Sigma-Aldrich

95468

Poly-(L-lactid)

vibrant-m

GF50233014

Poly L Lactic Acid - Biopolymer

Poly-(D-lactid) inherent viscosity ~1.2 dl/g

Sigma-Aldrich

67122

Poly-(D-lactid)

vibrant-m

GF45989881

Polylactic Acid - Biopolymer

Poly(D,L-lactide) acid terminated, average Mw 15000

Sigma-Aldrich

805734

Poly(D,L-lactide)

Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)

Artikel

Professor Aran (Claremont University, USA) thoroughly discusses the engineering of graphene based materials through careful functionalization of graphene oxide, a solution processable form of graphene.

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

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