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Sigma-Aldrich

Tricarbonyldichlorruthenium(II)-dimer

Synonym(e):

CORM-2

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About This Item

Lineare Formel:
[Ru(CO)3Cl2]2
CAS-Nummer:
22594-69-0
Molekulargewicht:
512.01
MDL-Nummer:
MFCD00011528
UNSPSC-Code:
12161600
PubChem Substanz-ID:
24857320
NACRES:
NA.22

Qualitätsniveau

100

Eignung der Reaktion

core: ruthenium
reagent type: catalyst

SMILES String

[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl

InChI

1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4

InChIKey

JYHHJVKGDCZCCL-UHFFFAOYSA-J

Verwandte Kategorien

Anwendung

Carbon monoxide-releasing molecule used for pharamological studies including:
  • Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
  • Investigations of P2X4 as a possible target
  • Possible modification of thrombus growth or disintegration
  • Enhances fibrinogen as a substrate for thrombin
  • Regulation of ion transport by gasotransmitters

Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12)
Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO.
Roberto Motterlini et al.
Circulation research, 90(2), E17-E24 (2002-02-09)
Carbon monoxide (CO) is generated in living organisms during the degradation of heme by the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible (HO-1) isoforms. Carbon monoxide gas is known to dilate blood vessels in a
V G Nielsen et al.
Human & experimental toxicology, 36(7), 727-733 (2016-08-05)
Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of
Yu Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 36(6), 791-795 (2016-12-08)
Carbon monoxide (CO), as a vital small molecule in signaling pathways, is found to be involved in ischemia-reperfusion injury (IRI) in renal transplantation. CO-releasing molecule-2 (CORM-2), a CO-releasing molecule, is a type of metal carbonyl complexes which can quickly release
Po-Min Yang et al.
Vascular pharmacology, 87, 209-218 (2016-10-11)
The production of nitric oxide (NO) by endothelial NO synthase (eNOS) plays a major role in maintaining vascular homeostasis. This study elucidated the potential role of carbon monoxide (CO)-releasing molecules (CORMs) in NO production and explored the underlying mechanisms in
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