- Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer.
Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer.
Infection and immunity (2006-09-20)
Kazunori Gomi, Toshiaki Kikuchi, Yutaka Tokue, Shigeru Fujimura, Akiko Uehara, Haruhiko Takada, Akira Watanabe, Toshihiro Nukiwa
PMID16982829
ZUSAMMENFASSUNG
Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.
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